中国药业2017，Vol.26Issue(8)：29-32,4.DOI:10.3969/j.issn.1006-4931.2017.08.008
不同口服剂量氟康唑预防新生儿重症监护室高危患儿真菌感染临床观察
Different Oral Dose of Fluconazole in Preventing High-Risk Children Patients with Fungal Infection in Neconatal Intensive Care Unit
摘要
Abstract
Objective To evaluate the effect of prophylaxis administration of fluconazole by oral with two frequently-used doses in preventing fungal infection in NICU. Methods 125 patients used Fluconazole to prevent fungal infection from April 2014 to October 2015 in NICU of our hospital were selected and divided into group A(n=56) and group B(n=69) according to different dosage, group A:3 mg/kg,twice a week,group B:6 mg/kg,once two days,for 4 weeks,collect related information for statistical analysis. Results After preventive medication,the fungal infection rate of group A was 5. 36%,and the group B was 4. 35%,the differences had no sta-tistical significance(P > 0. 05);group A with 10. 71% incidence of transaminase eleations,group B with 18. 84% incidence of transam-inase eleations,it had statistically difference(P < 0. 05). Conclusion In NICU for high-risk children patients using small doses,low frequency of fluconazole to prevent fungal infection,is a more appropriate choice.关键词
口服/氟康唑/预防/新生儿重症监护室/高危患儿/真菌感染/剂量选择Key words
oral/Fluconazole/prophylaxis/neonatal intensive care unit(NICU)/high-risk children patients/fungal infection/dose selection分类
医药卫生引用本文复制引用
翁小红,王三南,尚尔宁,唐莲..不同口服剂量氟康唑预防新生儿重症监护室高危患儿真菌感染临床观察[J].中国药业,2017,26(8):29-32,4.基金项目
2013年苏州市科技发展计划指导性项目[ SYSD2013147 ]. （）
