中国药业2017，Vol.26Issue(8)：43-46,4.DOI:10.3969/j.issn.1006-4931.2017.08.012
奥氮平与利培酮治疗脑器质性精神障碍疗效和安全性比较
Efficacy and Safety Comparison of Olanzapine and Risperidone in Treating Brain Organic Mental Disorders
摘要
Abstract
Objective To compare the clinical efficacy and safety of Olanzapine and Risperidone in the treatment of brain organic men-tal disorders. Methods A total of 60 patients with brain organic mental disorder patients were selected and divided into the Olanzapine group and Risperidone group in accordance with the random number table method,30 cases in each group. Oral treatment of the re-spective drugs were taken,and both groups were treated for 6 weeks. Before treatment and 2,4,6 weeks after treatment,the positive and negative symptoms scale(PANSS)was used to evaluate the efficacy,and the adverse reaction was assessed by TESS. Results After the 6-weeks treatment,the PANSS scores of the two groups were significantly lower than those before treatment(P < 0. 01). There was no significant difference between the two groups in the total efficiency rate and the total effective rate(P > 0. 05). The incidence of EPS in the Olanzapine group was significantly lower than that in the Risperidone group(P < 0. 05),and the incidence of insomnia was sig-nificantly lower than the Risperidone group(P < 0. 01). There was no significant difference in the incidence of other adverse reactions between the two groups(P > 0. 05). Conclusion Olanzapine and Risperidone have a significant effect on organic mental disorders with high safety and good compliance. Thus,we can choose either of them according to the clinical needs.关键词
器质性精神障碍/奥氮平/利培酮/疗效/安全性Key words
organic mental disorders/Olanzapine/Risperidone/efficacy/safety分类
医药卫生引用本文复制引用
徐兴红,邓丽凤..奥氮平与利培酮治疗脑器质性精神障碍疗效和安全性比较[J].中国药业,2017,26(8):43-46,4.
