中国医院用药评价与分析2017，Vol.17Issue(4)：472-473,476,3.DOI:10.14009/j.issn.1672-2124.2017.04.015
负荷剂量阿托伐他汀对急性冠状动脉综合征患者经皮冠状动脉介入治疗围术期的影响
Effects of Loading dose Atorvastatin on Acute Coronary Syndromes During Perioperative Period
李帅 1刘兵2
作者信息
- 1. 商丘市第一人民医院心血管内科,河南 商丘 476000
- 2. 商丘职业技术学院园林食品加工系,河南 商丘 476000
- 折叠
摘要
Abstract
OBJECTIVE:To probe into the effects of loading dose atorvastatin on acute coronary syndromes (ACS) during perioperative period.METHODS: 120 patients with ACS admitted from Jul.2014 to Dec.2015 were selected to be divided into observation group and control group via the random number table, with 60 cases in each.Two groups were given conventional treatment before and after percutaneous coronary intervention (PCI), based on which, the observation group received dose of 80 mg atorvastatin before PCI and 40 mg after PCI orally.The creatine kinase isoenzymes (CK-MB), cardiac troponin I (cTnI), and high sensitive C-reactive protein (hs-CRP) levels of two groups were compared before and after PCI of 8 hours, 24 hours, and the incidence of major adverse cardiac events(MACE)were recorded.RESULTS: After PCI, the CK-MB, cTnI and hs-CRP levels of two groups increased significantly, yet the increasing range of various indicators of observation group was lower than those of control group, with statistically significant difference(P<0.05).The incidence of MACE in control group was 13.33%(8/60), significantly higher than that of observation group [5.00%(3/60)], with statistically significant difference(P<0.05).Of the MACE cases, nonfatal myocardial infarction was common.CONCLUSIONS: Atorvastatin can reduce PCI-related myocardial injury, improve the prognosis of patients and reduce the incidence of MACE.关键词
急性冠脉综合征/阿托伐他汀/炎症反应/经皮冠状动脉介入治疗Key words
Acute coronary syndrome/Atorvastatin/Inflammatory response/Percutaneous coronary intervention分类
医药卫生引用本文复制引用
李帅,刘兵..负荷剂量阿托伐他汀对急性冠状动脉综合征患者经皮冠状动脉介入治疗围术期的影响[J].中国医院用药评价与分析,2017,17(4):472-473,476,3.
