中国真菌学杂志2017，Vol.12Issue(2)：86-88,91,4.
脑脊液(1,3)-β-D-葡聚糖在颅内真菌感染诊治的价值
Clinical values of (1,3)-β-D-glucan in cerebrospinal fluid of patients with fungal meningitis
摘要
Abstract
Objective To evaluate the utility of (1,3)-β-D-glucan (BDG)as an assist diagnostic tool for patients infected with fungal meningoencephalitis.To investigate the change of BDG level following the administration of antifungal drug in fungal meningoencephalitis patients,evaluate the monitor value of BDG in cerebrospinal fluid (CSF) for fungal meningoencephalitis.Methods BDG concentrations of 10 cerebrospinal fluid (CSF) specimens from confirmed cases of fungal meningoencephalitis,and 30 negative control CSF specimens were tested.And we also assessed whether BDG levels correlate with clinical status by using incident samples from 10 patients with serially collected CSF.Results The level of BDG in CSF was obviously rise in those confirmed cases of fungal meningoencephalitis,the data had a statistically significant difference (P ＜ 0.05).Patients with serially collected CSF displayed that patients with a decline in CSF BDG had clinical improvement.Conclusions Our data suggest that measuring BDG in CSF is a highly sensitive test for diagnosis of fungal meningoencephalitis.Analysis of BDG levels in serially collected CSF demonstrated that BDG may correlate with clinical response and course of treatment.Routine measurement of BDG in CSF may provide useful adjunctive data for the clinical management of patients with meningoencephalitis.关键词
(1,3)-β-D-葡聚糖/真菌性颅内感染/MB-80微生物快速动态监测系统Key words
(1-3)-β-D-Glucan/fungal meningoencephalitis/MB-80rapid microbial monitoring system分类
医药卫生引用本文复制引用
王兴,杨柳,贺曦,张敏..脑脊液(1,3)-β-D-葡聚糖在颅内真菌感染诊治的价值[J].中国真菌学杂志,2017,12(2):86-88,91,4.基金项目
重庆市卫生局医学科研计划项目(2013-2-101) （2013-2-101）
