摘要
Abstract
Objective To observe the dynamic changes of CD3+T cells, CD3+CD4+T cells, CD3+CD8+T cells and CD4+CD25+FoxP3+ regulatory T cells (Tregs) in peripheral blood of patients with acute stroke, and explore the immune state and its influence on infection after stroke. Methods There were 32 acute stroke patients in stroke group, and 23 age- and gender-matched healthy ones in control group. According to infection occurring within 1 week after stroke or not, 32 stroke patients were divided into infection group (n=8) and non-infection group (n=24). The levels of CD3+T cells, CD3+CD4+T cells, CD3+CD8+T cells and Tregs were determined serially on day 1, 3 and 7 after stroke onset in 32 stroke patients and 23 controls. Results ①Comparing with the control group, CD3+CD4+T cells and Tregs increased on day 7 after onset (P=0.02 and 0.03, respectively), CD3+CD8+T cells decreased on day 1 and 3 after onset (P=0.01 and 0.03, respectively) and restored to a normal level on day 7 in non-infection group. A significant fall of CD3+T cells, CD3+CD4+T cells, CD3+CD8+T cells and Tregs were observed on day 1 (P<0.001,<0.001, 0.03 and <0.001, respectively), 3 (P<0.001), and 7 (P<0.001, 0.01, 0.01 and 0.01, respectively) after onset in infection group. ②Comparing with non-infection group, CD3+T cells, CD3+CD4+T cells, and Tregs were all significantly lower on day 1 (P=0.01, <0.001 and <0.001, respectively), 3 (P<0.001,<0.001 and 0.04, respectively) and 7 (P<0.001) after onset in infection group. There was no significant difference in CD3+CD8+T cells between the two stroke groups on day 1, while this type of T cells in infection group significantly decreased on day 3 (P<0.001) and 7 (P=0.02) after onset than that of in non-infection group. Conclusion CD3+T cells, CD3+CD4+T cells, CD3+CD8+T cells and Tregs may involve in pathophysiological process in the acute phase of stroke. The dynamic changes of T lymphocytes may induce to immunodepression, and involve in infection after stroke.关键词
卒中/T淋巴细胞亚群/调节性T细胞/免疫抑制/感染Key words
Stroke/T lymphocyte subsets/Regulatory T cells/Immunodepression/Infection
