中国卒中杂志2017，Vol.12Issue(5)：410-414,5.DOI:10.3969/j.issn.1673-5765.2017.05.007
动脉粥样硬化性脑梗死外周血辅助性T细胞17表达水平研究
The Role of Th17 in Stroke in Patients with Acute Atherosclerotic Cerebral Infarction
摘要
Abstract
Objective To explore the role of T helper cell 17 (Th17) in stroke evolving by detecting the level of Th17 in peripheral blood and its relationship with carotid artery intima-media thickness (IMT) in patients with acute atherothrombotic ischemic stroke. Methods Patients with first-ever acute atherosclerosis cerebral infarction were included in the stroke group, and the baseline characteristics matched healthy people as control. The levels of Th17 in peripheral blood between the two groups were compared. According to the National Institute of Health Stroke Scale (NIHSS) score at admission, the patients in stroke group were divided into light stroke, medium stroke and severe stroke subgroups. The level of Th17 between the two groups and among the three subgroups were compared. The relationship between the level of Th17 and risk factors of the patients such as age, gender, hypertension, diabetes, hyperlipidemia were analyzed. The correlation between Th17 and carotid artery intima-media thickness (IMT) was also analyzed. Results All the subjects from the stroke group (n=45) and control group (n=32) were investigated. The level of Th17 in stroke group was significantly higher than that in control group ([7.41±1.93]%vs [2.8±0.64]%, P<0.001). The percentage of Th17 in peripheral blood mononuclear cells in light stroke (4.97±0.89)%, medium stroke (7.06±1.33)% and severe stroke subgroup (8.65±1.71)% were all significantly higher than that in control group (all P value<0.001). The level of Th17 in medium stroke subgroup was higher than that in light stroke subgroup (P=0.003). The level of Th17 in severe stroke subgroup were higher than that in medium (P=0.002) and light stroke subgroup (P=0.002). There was a significantly positive correlation between the level of Th17 and IMT (r=0.68, P<0.001). Conclusion Elevated level of Th17 may enhance vascular inflammation and accelerate atherosclerotic cerebral infarction, and Th17 may involve in the pathogenesis of stroke.关键词
动脉粥样硬化/脑梗死/外周血辅助性T细胞17/颈动脉内-中膜厚度Key words
Atherosclerosis/Acute cerebral infarction/T helper 17 cells/Intima-media thickness引用本文复制引用
任青青,钱伟东..动脉粥样硬化性脑梗死外周血辅助性T细胞17表达水平研究[J].中国卒中杂志,2017,12(5):410-414,5.基金项目
2015年度研究生科研创新计划项目(Byycx1520) （Byycx1520）
