针灸临床杂志2017，Vol.33Issue(3)：53-56,4.
电针对2型糖尿病大鼠糖代谢及血清SOD、MDA含量的影响
Effect of Electro-acupuncture on Oxidative Stress and Glucose Metabolism in Rats with Type 2 Diabetes
摘要
Abstract
Objective:To observe the effect of electro-acupuncture (EA) on oxidative stress and glucose metabolism in rats with type 2 diabetes (T2DM),so as to study its mechanism of improving T2DM.Methods:40male SD rats were evenly randomized into control,model,"Weiwan Xiashu"," Housanli" and Glimepiride groups,with 8 rats in each group.The T2DM models were established by feeding high fat and sugar diet combined with intra-peritoneal injection of streptozotocin (35mg/kg).Electro-acupuncture (2 Hz,2 mA) was applied as the intervention,20 minutes every time,6 times per week,lasting for 4 weeks.Body quality and fasting blood glucose (FBG) were measured once a week during the intervention.Fasting serum insulin (FINS),serum malondialdehyde (MDA) and superoxide dismutase (SOD) levels were determined by using radioimmunoassay.Oral glucose tolerance test was measured before and after the intervention.In addition,homeostasis model assessment for insulin resistance (HOMA-IR) and modified B cell function index (MBCI) were calculated.Results:The fasting blood glucose was decreased to a certain extent with the application of electro-acupuncture at Weiwan Xiashu and Housanli.After 4 weeks,FINS and HOMA-IR of T2DM rats were decreased,and the Weiwan Xiashu group was the best(P ＜0.01).Compared with those of the control group,FBG and MDA levels of model group were both increased.However,SOD activities were decreased(P ＜ 0.05).Compared with those of the model group,SOD activities of Weiwan Xiashu,Housanli groups were increased (P ＜ 0.05)and MDA levels were decreased (P ＜ 0.05).There was no statistical significance between the Glimepiride group and the model group (P ＞ 0.05).Conclusion:Electro-acupuncture at Weiwan Xiashu and Housanli can reduce fasting blood glucose and may normalize insulin sensitivity,ameliorate insulin resistance and hyperinsulinemia by improving the oxidative stress state as a whole.关键词
电针/2型糖尿病/糖代谢/氧化应激Key words
Electro-acupuncture/Type 2 diabetes/Glucose metabolism/Oxidative stress分类
医药卫生引用本文复制引用
马艳佳,李瑞,贾宁,胡晓刚,王跃颖,田环环,曹昺焱,张淑静..电针对2型糖尿病大鼠糖代谢及血清SOD、MDA含量的影响[J].针灸临床杂志,2017,33(3):53-56,4.基金项目
教育部科学技术研究重大项目,编号:313010. （）
