针灸临床杂志2017，Vol.33Issue(3)：61-65,封3,6.
针刀干预对帕金森病模型大鼠行为学及谷胱甘肽的影响
Effect of Acupotomy on the Ethology Changes and GSH Content of PD Model Rats
摘要
Abstract
Objective:To observe the effect of acupotomy on the changes of ethology and glutathione (GSH) contents of substantia nigra in model rats with Parkinson's disease.Methods:Healthy male SD rats were randomly divided into a blank group,a model group,an electroacupuncture (EA) group and an acupotomy group,with sixteen rats in each group.PD rat models were set up by unilateral striatum injection of 6-OHDA with two targets.Rats in EA group were treated by EA at "Baihui" (GV 20) and "Taiyang" (EX-HN5).Acupotomy group chose midpoint of the occipital bone inferior nuchal line and transverses process posterior tubercle C1 and C2 to debond and release.After treatment,rats were tested for rotational behavior and assessed the GSH content of midbrain substantia nigra.Results:The blank group had no rotation behavior,and the model group had no difference before and after intervention (P ＞ 0.05).In acupotomy group rotations were decreased significantly after treatment compared with those before treatment (P ＜ 0.01),and EA group had a significant difference before and after treatment(P ＜0.05).The comparison of GSH contents among each group showed that the GSH contents of model group were significantly decreased compared with those of the blank group (P ＜ 0.01).GSH contents of acupotomy group and EA group were increased significantly after the intervention,and the acupotomy group was significantly different from model group (P ＜ 0.05).Conclusion:Acupotomy can improve the rotational behavior of PD model rats and increase GSH contents,and it may be by improving the antioxidant capacity to reduce the damage of DA neurons in substantia nigra.关键词
针刀干预/帕金森病/氧化应激/谷胱甘肽Key words
Acupotomy intervention/Parkinson's disease/Oxidative stress/Glutathione分类
医药卫生引用本文复制引用
梁靖蓉,马田,陈晨,安娜,卢胜春,郭长青,芦娟,杜宁宇,马薇薇,朴起范,吴彤,徐菁,赵瑞利..针刀干预对帕金森病模型大鼠行为学及谷胱甘肽的影响[J].针灸临床杂志,2017,33(3):61-65,封3,6.基金项目
江西德兴市胜春医院课题,编号:535104032. （）
