浙江医学2017，Vol.39Issue(5)：345-349,361,6.DOI:10.12056/j.issn.1006-2785.2017.39.5.2016-846
重症川崎病患儿的临床特点及预测指标分析
Clinical manifestations and predictors of severe Kawasaki Disease
摘要
Abstract
Objective To analyze the clinical manifestations and predictors of severe Kawasaki disease (SKD).Methods Nineteen pediatric KD patients with single or multiple severe organ damage and unstable vital signs,and 76 KD children without organ damage and stable vital signs (control group) admitted during 2010-2015 were enrolled in the study.Clinical manifestations,laboratory findings,treatment and prognosis were reviewed.The risk factors of severe Kawasaki disease were analyzed by ROC curve and multivariate Logistic regression.Results The average age of SKD patients was older than that of control group (P＜0.05).SKD patients were more likely to have lymphadenitis,higher neutrophil counts,C-reactive protein,transaminase and bilirubin levels,lower serum sodium and albumin levels,a higher risk of coronary artery lesion,and no response to intravenous immunoglobulin (IVIG) therapy(all P＜0.05).Furthermore,ROC curve and Multivariate Logistic regression analysis showed that age (≥ 37.5 months),percentage of neutrophils (N ≥ 0.821),TBil (≥ 22.05μmol/L),and serum sodium (≤ 133.55mmol/L) were independent predictors for SKD.Conclusion Older children,higher percentage of neutrophils,higher bilirubin,lower sodium level might be used for predicting SKD.And SKD patients had a higher risk of coronary artery lesion and resistance to IVIG therapy.关键词
川崎病/重症/冠状动脉损害/丙种球蛋白无反应/预测指标Key words
Kawasaki disease/Severe/Coronary artery lesions/IVIG nonresponsiveness/Predictors引用本文复制引用
何跃娥,吴蓉洲,褚茂平,仇慧仙,张园海,项如莲..重症川崎病患儿的临床特点及预测指标分析[J].浙江医学,2017,39(5):345-349,361,6.基金项目
浙江省自然科学基金资助项目(LQ16H020008) （LQ16H020008）
浙江省中医药管理局项目(2010ZA092) （2010ZA092）
浙江省医药卫生科技项目(2017KY465) （2017KY465）
