浙江医学2017，Vol.39Issue(5)：358-361,4.DOI:10.12056/j.issn.1006-2785.2017.39.5.2016-790
COPD营养不良大鼠下丘脑瘦素受体活化后STAT3、SOCS3的表达研究
Expression of STAT3 and SOCS3 following leptin receptor activation in hypothalamus in COPD rata with malnutrition
摘要
Abstract
Objective To investigate the expression of STAT3 and SOCS3 following leptin receptor activation in hypothalamus in COPD rats with malnutrition state.Methods Thirty SD rats were randomly divided into control group and COPD group with 15 in each group.Rats in COPD group received passive smoking for 24 weeks,then LPS 0.2ml was dripped in the airway at d30 and d45.All animals were sacrificed after experiments;serum leptin,triglycerides,VLDL were measured;and pathological examination of lung tissue was performed;relative expression of STAT3 and SOCS3 in hypothalamus was detected by Western-Blot.Results The body weight,and triglycerides,VLDL,leptin levels,and the expression of SOCS3 in COPD group were lower than those in normal group (all P＜0.01),while the expression of STAT3 was higher (P＜0.01).Conclusion The malnutrition state in COPD rats may be related to the leptin-mediated up-regulation of STAT3 expression and down-regulation of SOCS3 expression in hyothalamus.关键词
瘦素/慢性阻塞性肺疾病/营养不良/信号传导转录活化因子3/细胞因子信号传导抑制因子3Key words
Leptin/COPD/Malnutrition/STAT3/SOCS3引用本文复制引用
徐志波,陈芳,江劲..COPD营养不良大鼠下丘脑瘦素受体活化后STAT3、SOCS3的表达研究[J].浙江医学,2017,39(5):358-361,4.基金项目
国家自然基金项目(2012R10063) （2012R10063）
浙江省卫生厅一般项目(2013KYA140) （2013KYA140）
浙江省博士后科研资助项目(BSH1402070) （BSH1402070）
