浙江医学2017，Vol.39Issue(6)：438-441,4.DOI:10.12056/j.issn.1006-2785.2017.39.6.2016-698
乳腺癌中膜型基质金属蛋白酶-1蛋白表达及其临床病理意义
Expression of MT1-MMP in breast cancer and its correlation with clinicopathology
摘要
Abstract
Objective To investigate the expression of MT1-MMP protein in breast cancer and to evaluate its clinicopathologic significance.Methods The expression of MT1-MMP protein was detected by immunohistochemical EnVision method in 48 samples of normal breast tissues,64 cases of usual ductal hyperplasia (UDH),72 cases of ductal carcinoma in situ (DCIS) and 220 cases of invasive breast cancer.Results The expression rates of MT1-MMP protein in invasive breast cancer,DCIS Ⅲ,DCIS Ⅰ-Ⅱ,UDH and normal breast tissues were 67.73％(149/220),25.64％(10/39),6.06％(2/33),4.69％(3/64),18.75％ (9/48).The MT1-MMP protein expression in invasive breast cancer was significantly higher than those in DCIS Ⅲ,DCIS Ⅰ-Ⅱ,UDH and normal breast tissues (P＜0.01),and MT1-MMP protein expression in DCIS Ⅲ was significantly higher than those in DCIS Ⅰ-Ⅱ (P＜0.05) and UDH (P＜0.01).MT1-MMP protein expression in invasive breast cancer was increased with the increasing clinical stages (P＜0.01),and MT1-MMP protein positive rates in patients with axillary lymph node metastasis and negative PR status were significantly higher than those with negative axillary lymph node and positive PR (P＜0.01 and P＜0.05,respectively).Logistic regression analysis showed that axillary lymph node metastasis (OR=0.213,95％CI=0.084～0.544,P＜0.01) and PR status (0R=1.927,95％CI=1.049～3.542,P＜0.05) were independent factors of MT1-MMP protein expression in invasive breast cancer.Conclusion MT1-MMP protein expression shows significantly increasing trend from UDH,DCIS Ⅰ-Ⅱ,DCIS Ⅲ to invasive breast cancer,and its expression is correlated with unfavorable prognostic factors of invasive breast cancer,suggesting that MT1-MMP may play an important role in the progression of breast cancer and might be a potential anti-cancer therapy biological marker.关键词
膜型基质金属蛋白酶-1/乳腺癌/免疫组化/导管原位癌/普通型导管增生Key words
MT1-MMP/Breast cancer/Immunohistochemistry/DCIS/UDH引用本文复制引用
王超群,曾悦,王艳,黄必飞,孙鑫鑫,赵永明,王倩,胡桂女,苏振铭..乳腺癌中膜型基质金属蛋白酶-1蛋白表达及其临床病理意义[J].浙江医学,2017,39(6):438-441,4.基金项目
浙江省医药卫生科技计划项目(2012KYB230) （2012KYB230）
