浙江医学2017，Vol.39Issue(6)：449-451,465,4.DOI:10.12056/j.issn.1006-2785.2017.39.6.2016-2023
精神分裂症患者NLR、氧化应激参数与精神症状的相关性
Association between neutrophil/lymphocyte ratio and psychiatric symptoms in patients with schizophrenia
费小聪 1陈海支 1郑燕妮 2方瑜 1雷礼磊 1王振华 1宋宝华 1崔力军3
作者信息
- 1. 313000 湖州市第三人民医院精神科
- 2. 山西省晋城市人民医院医学影像科
- 3. 313000 湖州市第三人民医院检验科
- 折叠
摘要
Abstract
Objective To investigate the association between neutrophil/lymphocyte ratio(NLR) and psychiatric symptoms in patients with schizophrenia.Methods Sixty four patients with schizophrenia and 61 healthy volunteers were included in the study.The NLR,total antioxidant status(TAS),total oxidant status(TOS),oxidative stress index (OSI) and paraoxonase 1(PON1) and thiol levels were measured;the psychiatric symptoms were evaluated with positive and negative symptom table(PANSS).The association of psychiatric symptoms with NLR,PANSS score and oxidative stress parameters was analyzed.Results Compared with healthy controls,the NLR,TAS and TOS in schizophrenia group were increased significantly (P＜0.05),Thiol and Thiol/OSI were decreased significantly(P＜0.05).However,there were no significant differences in PON1 and OSI between two groups(P ＞ 0.05).PANSS positive score was negatively correlated with Thiol/OSl (r=-0.264) in schizophrenic patients,and the PANSS total score was positively correlated with NLR (r=0.251),and negatively correlated with Thiol/OSI (r=-0.286).There was a negative correlation between NLR and Thiol/OSI in schizophrenia group (r=-0.340),but not in control group (r=-0.040).NLR was positively correlated with TOS and OSl in schizophrenic patients (r=0.361,0.307).Thiol/OSI was negatively correlated with TOS and OSI (r=-0.685,-0.678),and positively correlated with TAS and Thiol (r=0.256,0.416).Conclusion Inflammation and oxidative stress may be involved in the occurrence and development of schizophrenia,and are closely related to the clinical symptoms of patients.NLR as a simple and inexpensive indicator may be used for assessment of oxidative stress and psychiatric symptoms in patients with schizophrenia.关键词
中性粒细胞/淋巴细胞比值/氧化应激参数/精神分裂症Key words
Neutrophil/lymphocyte ratio/Oxidative stress parameters/Schizophrenia引用本文复制引用
费小聪,陈海支,郑燕妮,方瑜,雷礼磊,王振华,宋宝华,崔力军..精神分裂症患者NLR、氧化应激参数与精神症状的相关性[J].浙江医学,2017,39(6):449-451,465,4.
