浙江医学2017，Vol.39Issue(6)：459-462,4.DOI:10.12056/j.issn.1006-2785.2017.39.6.2015-1394
放疗联合培美曲塞、卡铂同期及巩固化疗治疗中晚期食管癌的疗效评价
Radiotherapy combined with pemetrexed, carboplatin concurrent and consolidation chemotherapy in patients with unresectable esophageal cancer: a prospective phase Ⅱ study
李丽 1王谨 2郑远达 2喻冰淇 2陈建祥2
作者信息
- 1. 310022杭州,浙江省肿瘤医院超声科
- 2. 310022杭州,浙江省肿瘤医院放疗科
- 折叠
摘要
Abstract
Objective To evaluate the efficacy and safety of radiotherapy combined with pemetrexed,carboplatin concurrent and consolidation chemotherapy in patients with unresectable esophageal cancer.Methods Sixteen patients with local advanced esophagus carcinoma received 6MV X ray intensity-modulated radiation therapy with a total dose of 60Gy(30 fractions for 6 weeks) from 2009 to 2011.Chemotherapy consisted of pemetrexed 500mg/m2 and carboplatin (AUC=5) administered concurrently with radiotherapy and after radiotherapy.Tumor response was evaluated with thoracic CT scans performed 4 weeks after completion of treatment in accordance with RECIST 1.1 criteria.Adverse reaction were evaluated in accordance with CTCAE 3.0.Results All 16 patients completed treatment,with 1 case of complete remission (CR) and 15 cases of partial remission(PR).One-and 2-year survival rate was 69％ and 38％,and 1-and 2-year progression-free survival(PFS) rate was 44％ and 31％,respectively.Twelve patients died,11 died of cancer,1 died of other disease,and none died of treatment related toxicities.Seven patients developed grade 3/4 neutrocytopenia,and 7 developed grade 3/4 thrombocytopenia.Grade 3 acute esophagitis and pneumonitis were observed in 4 patients.Conclusion For unresectable esophageal cancer,radiotherapy combined with pemetrexed,carboplatin concurrent and consolidation chemotherapy is safe and the short-term outcomes are promising.Further investigations are warranted.关键词
食管癌/放疗/培美曲塞/卡铂/生存曲线/不良反应Key words
Esophageal cancer/Concurrent chemo-radiotherapy/Pemetrexed/Carboplatin/Survival curve/Adverse reaction引用本文复制引用
李丽,王谨,郑远达,喻冰淇,陈建祥..放疗联合培美曲塞、卡铂同期及巩固化疗治疗中晚期食管癌的疗效评价[J].浙江医学,2017,39(6):459-462,4.
