肿瘤防治研究2017，Vol.44Issue(4)：272-275,4.DOI:10.3971/j.issn.1000-8578.2017.04.007
胰岛素受体酪氨酸激酶底物p53蛋白在上皮性卵巢癌中的表达及其对患者预后的影响
Expression of IRSp53 in Epithelial Ovarian Carcinoma and Its Prognostic Significance
刘蓉 1秦嶽1
作者信息
- 1. 810000西宁,西宁市第一人民医院妇科
- 折叠
摘要
Abstract
Objective To analyse the IRSp53 expression and its prognostic significance in epithelial ovarian carcinoma tissues.Methods The expressions of IRSp53 in 76 cases of epithelial ovarian carcinoma were detected by SP immunohistochemical technique.The relationship between the IRSp53 expression and the clinical pathological characteristics and the pathological grading of the patients was analyzed.The prognostic significance of IRSp53 in epithelial ovarian carcinoma was discussed.Results The expression of IRSp53 was significantly correlated with FIGO stage (Z=-3.526,P＜0.05),histopathological grading(Z=-2.471,P＜0.05),pathologic type (Z=-2.305,P＜0.05),lymph node metastasis (Z=1.124,P＜0.05) and CA125 level (Z=1.462,P＜0.05).There was a positive correlation between the expression intensity of IRSp53 and pathological grade(r=0.779,P＜0.05).The 5-year cumulative survival rate of the patients with low IRSp53 expression was significantly higher than that with high IRSp53 expression(x2 =5.018,P＜0.05).Conclusion IRSp53 plays an important role in the development of epithelial ovarian carcinoma,and the over-expression of IRSp53 may lead to poor prognosis.关键词
上皮性卵巢癌/IRSp53/预后Key words
Epithelial ovarian cancer/IRSp53/Prognosis分类
医药卫生引用本文复制引用
刘蓉,秦嶽..胰岛素受体酪氨酸激酶底物p53蛋白在上皮性卵巢癌中的表达及其对患者预后的影响[J].肿瘤防治研究,2017,44(4):272-275,4.
