肿瘤防治研究2017，Vol.44Issue(4)：295-297,3.DOI:10.3971/j.issn.1000-8578.2017.04.012
KRT81rs3660变异对肺癌发病风险的影响
Effect of KRT81 rs3660 Polymorphism on Risk of Lung Cancer
摘要
Abstract
Objective To explore the association of rs3660 polymorphism in the 3'UTR of KRT81 with the susceptibility for lung cancer.Methods The genotypes of rs3660 were determined by TaqMan-MGB realtime PCR.The OR and 95％CI were estimated by Logistic regression to evaluate the association of rs3660 polymorphism with the risk of non-small cell lung cancer(NSCLC) and small cell lung cancer(SCLC).Results KRT81 rs3660G＞C variant affected the risk of SCLC (P=0.048),not NSCLC (P=0.614).When compared with the individuals with rs3660GG genotype,a significant decreased risk of developing SCLC was shown in C allele carriers (OR=0.70,95％CI:0.49-0.99).When stratified by smoking status,C allele carriers had significantly decreased risk among non-smokers (OR=0.60,95％CI:0.36-0.99,P=0.049).We also found that C allele carriers had no significantly decreased risk among light smokers (or heavy smokers) (OR=0.61,95％CI:0.26-1.43,P=0.254).Conclusion KRT81 rs3660G＞C polymorphism contributes to the risk of SCLC,not NSCLC.关键词
KRT81/遗传变异/肺癌/单核苷酸多态Key words
KRT81/Genetic variants/Lung cancer/SNP分类
医药卫生引用本文复制引用
杨振邦,林佳,曹蕾,张艳艳,郭锦翠,牛泽人,张雪梅..KRT81rs3660变异对肺癌发病风险的影响[J].肿瘤防治研究,2017,44(4):295-297,3.基金项目
国家自然科学基金(81272613) （81272613）
唐山市科技创新团队培养计划(14130225B) （14130225B）
河北省普通高等学校高层次人才科学研究计划(GCC2014050) （GCC2014050）
