肿瘤防治研究2017，Vol.44Issue(4)：298-302,5.DOI:10.3971/j.issn.1000-8578.2017.04.013
内质网应激/未折叠蛋白反应促进肿瘤侵袭的研究进展
Advances of Endoplasmic Reticulum Stress/Unfolded Protein Response Promote Tumor Invasion
摘要
Abstract
Endoplasmic reticulum stress/unfolded protein response is a new regulatory mechanism that promote tumor invasion.Moderate endoplasmic reticulum stress can not only protect the cells but also promote cell invasive.Many studies have shown that endoplasmic reticulum stress/unfolded proteins response is closely related to the development of tumor and can promote tumor invasion through regulate the expression of the Vascular endothelial growth factor(VEGF),glucose-regulated protein78(GRP78),anterior gradient 2(AGR2),promote the transformation of epithelial mesenchymal and degrade extracellular matrix.Understand thelinks between endoplasmic reticulum stress/unfolded protein response and tumor invasion may provide a new direction for tumor treatment.In this article,we will review summarize the current knowledge about the relevant mechanism of endoplasmic reticulum stress/unfolded proteins response promote tumor invasion.关键词
内质网应激/侵袭/血管内皮生长因子/上皮间质转化/葡萄糖调节蛋78/前梯度蛋白2/细胞外基质Key words
Endoplasmic reticulum stress/Invasion/VEGF/Epithelial-mesenchymal transition/GRP78/AGR 2/Extracellular matrix分类
医药卫生引用本文复制引用
于涛,柴双,欧阳仲瑞,刘耀华..内质网应激/未折叠蛋白反应促进肿瘤侵袭的研究进展[J].肿瘤防治研究,2017,44(4):298-302,5.基金项目
国家自然科学基金(81372701) （81372701）
