中医药学报2017，Vol.45Issue(1)：21-24,4.
生、炒酸枣仁相伍对慢性应激抑郁症小鼠DA系统作用机制研究
Mechanism of Compatibility of SZS and Its Processing on Dopaminergic System of Chronic Stress Depression Mice
摘要
Abstract
Objective:To explore the antidepressant effect and the influence of compatibility of SZS and its processing on dopamine system of chronic stress depression mice.Methods:The ICR mice were randomly divided into four groups,with 20 mice in each group,respectively,compatibility group,model group,blank group and fluoxetine group.The chronic stress depression models were duplicated by the combination of solitary feeding and chronic unpredictable stimulation for 21 days.From the 11 th day after the models were established,the mice in compatibility group and model group were respectively treated with 10 g/(kg· d) of combined fried decoction and 10 rag/(kg·d) of fluoxetine solution for 11 days.The blank and model groups were treated with the same volume of distilled water for 11 days.Detect 5-HT content by ELISA of cortex in frontal lobe and hippocampus of mice.Detect Slc6a3 gene expression quantity in hippocampus of mice.Results:Compared with that of model group,the DA content in mice hippocampus of compatibility group was significantly higher (P ＜ 0.05),and the Slc6a3 gene expression quantity in mice hippocampus of compatibility group was significantly down-regulated.Conclusion:The mechanism of antidepressant effect of compatibility of SZS and its processing may be related to the inhibition of DA reuptake leading to the incease of synaptic DA content in some brain regions of mice.关键词
生、炒酸枣仁相伍/慢性应激抑郁模型/DAKey words
Compatibility of SZS and its processing/Chronic stress depression models/DA分类
医药卫生引用本文复制引用
王文凯,张贺,李廷利..生、炒酸枣仁相伍对慢性应激抑郁症小鼠DA系统作用机制研究[J].中医药学报,2017,45(1):21-24,4.基金项目
国家自然科学基金项目(81274114) （81274114）
黑龙江省自然科学基金项目(H201471) （H201471）
