中医药信息2017，Vol.34Issue(2)：1-4,4.
关黄柏对对乙酰氨基酚诱导大鼠急性肝损伤的保护作用
Protective Effect of Phellodendri Amurensis Cortex on Acetaminophen-induced Acute Hepatic Injury in Rats
摘要
Abstract
Objective:To investigate the protective effect of Phellodendri Amurensis Cortex on acetaminopheninduced acute hepatic injury in rats.Methods:Liver injury models were induced by subcutaneous injection of acetaminophen.Twenty-four hours later,the activities of serum alanine aminotransferase (ALT),aspartate aminotransferase (AST) and alkaline phosphatase (ALP) were determined,and the liver tissues were collected for histopathological assessment by HE staining under light microscope.The contents of glutathione (GSH)and malondialdehyde (MDA) in liver homogenate were also measured.Results:Compared with the normal control group,the model group could markedly increase serum ALT,AST and ALP activities,and the degeneration and necrosis could be observed in liver tissues.Compared with the model group,Phellodendri Amurensis Cortex could markedly decrease serum ALT,AST and ALP activities,reduce the MDA level in liver homogenate,and increase the content of GSH in the liver homogenate.The hepatic histopathological changes in liver were also significantly ameliorated.Conclusion:The Phellodendri Amurensis Cortex can prevent the liver from acetaminophen-induced acute hepatic injury.关键词
关黄柏/对乙酰氨基酚/急性肝损伤Key words
Phellodendri Amurensis Cortex/Acetaminophen/Acute hepatic injury分类
医药卫生引用本文复制引用
刘华,薛娟,唐振球,吴高松,王知斌,王秋红,匡海学..关黄柏对对乙酰氨基酚诱导大鼠急性肝损伤的保护作用[J].中医药信息,2017,34(2):1-4,4.基金项目
国家重点基础研究发展计划(973)项目(No.2013CB531801) （973）
国家自然科学基金面上项目(No.81473351) （No.81473351）
