重庆医学2017，Vol.46Issue(13)：1765-1767,3.DOI:10.3969/j.issn.1671-8348.2017.13.012
右美托咪定对肝门阻断手术血浆SDF-1表达水平的影响
Effect of dexmedetomidine on plasma SDF-1 levels in hepatic portal occlusion operation
摘要
Abstract
Objective To observe the effect of dexmedetomidine on plasma SDF-1 level in in hepatic portal occlusion operation.Methods Fifty patients with live cancer undergoing elective partial hepatectomy were selected,no gender limitation,aged 42 to 71,body mass index(BMI) 18.5 ～ 26.0 kg/m2,ASA grade Ⅱ or Ⅲ.The patients were randomly divided into 2 groups(n=25):control group and dexmedetomidine group.The dexmedetomidine group was performed the pump injection of dexmedetomidine 1 μg/kg at 15 min before induction of anesthesia.After induction the rate was changed to 0.4μg · kg-1 · h-1 until 15 min before the end of operation;the control group adopted the same method for conducting continuous intraverous infusion of the same capaci ty of 0.9％ sodium chloride.The peripheral venous blood was collected in 2 groups at preoperative 1 h (T0),postoperative 1 h (T1),postoperative 1 d (T2),postoperative 3 d(T3).The plasma SDF-1 level was detected by using enzyme-linked immunosorbent assay(ELISA).Results There was no statistically significant difference in liver resection range,blood loss,first porta hepatis vessel occlusion time,anesthesia time and plasma SDF-1 level before surgery between the two groups (P＞0.05).Compared with pre-operation,plasma SDF-11evel at T1,T2,T3 time point was significantly increased (P＜0.05).The plasma SDF-1 level at T1,T2,T3 time point in the dexmedetomidine group was lower than that in the control group(P＜0.05).Conclusion SDF-1 expression is significantly increased during perioperative period in the patients with hepatic portal occlusion operation,and intraoperative continuous dexmedetomidine can significantly reduce the SDF-1 level,which inhibits the chemotaxis and accumulation of inflammatory ceils to some extent.关键词
右美托咪定/肝门阻断术/基质细胞衍生因子-1/围术期Key words
Dexmedetomidine/hepatic portal occlusion operation/stromal cell derived factor-1/perioperation分类
医药卫生引用本文复制引用
杨贞,甯交琳,顾健腾,易斌,鲁开智..右美托咪定对肝门阻断手术血浆SDF-1表达水平的影响[J].重庆医学,2017,46(13):1765-1767,3.基金项目
国家自然科学基金资助项目(81270510). （81270510）
