动物营养学报2017，Vol.29Issue(4)：1091-1095,5.DOI:10.3969/j.issn.1006-267x.2017.04.001
Kelch样环氧氯丙烷相关蛋白-核因子E2相关因子2-抗氧化反应元件信号通路在氧化应激中的作用及其调控剂
Role of Kelch-Like Epichlorohydrin-Associated Protein 1-Nuclear Factor-E2-Related Factor 2-Antioxidant Response Element Signaling Pathway in Anti-Oxidative Stress and Its Regulators
摘要
Abstract
Kelch-like epichlorohydrin-associated protein 1-nuclear factor-E2-related factor 2-antioxidant re-sponse element ( Keap1-Nrf2-ARE ) signaling pathway is one of the most important cellular defense mecha-nisms against oxidative stress and xenobiotic damage, and it is closely associated with inflammatory diseases, including cancer, neurodegenerative diseases, cardiovascular diseases, aging and so on. Activation of Nrf2 sig-naling induces the transcriptional regulation of ARE-dependent expression of various detoxifying and antioxidant defense enzymes and proteins. Keap1-Nrf2-ARE signaling pathway has become an attractive target for the pre-vention and treatment of oxidative stress-related diseases and inflammatory diseases. Oxidative stress, the role of Keap1-Nrf2-ARE signaling pathway in anti-oxidative stress and the regulators of Keap1-Nrf2-ARE signaling pathway were reviewed in this paper.关键词
氧化应激/Keap1-Nrf2-ARE信号通路/调控剂Key words
oxidative stress/Keap1-Nrf2-ARE signaling pathway/regulators分类
农业科技引用本文复制引用
马燕芬,吴志红,赵磊,高民..Kelch样环氧氯丙烷相关蛋白-核因子E2相关因子2-抗氧化反应元件信号通路在氧化应激中的作用及其调控剂[J].动物营养学报,2017,29(4):1091-1095,5.基金项目
国家自然科学基金(30460616, 31601975) （30460616, 31601975）
内蒙古自然科学基金(2014BS0348) （2014BS0348）
内蒙古农牧业科学院青年创新基金(2015QNJJM07) （2015QNJJM07）
国家现代农业(奶牛)产业技术体系项目(CARS-37) （奶牛）
