儿科药学杂志2017，Vol.23Issue(5)：1-3,3.DOI:10.13407/j.cnki.jpp.1672-108X.2017.05.001
深圳市婴儿感染B族链球菌的克林霉素诱导型耐药研究
Inducible Resistance to Clindamycin in Group B Streptococcus Isolated from Infants in Shenzhen
摘要
Abstract
Objective:To explore the resistance rate of group B Streptococcus (GBS) to erythromycin and clindamycin and phenotype of resistance to macrolides,lincosamides and type B streptogramin(MLSB) in infected infants.Methods:The antimicrobial susceptibility of GBS to erythromycin and clindamycin were determined by the disk diffusion technique in Mueller-Hinton agar.The inducible resistance of erythromycin to clindamycin was detected by D test.Results:Thirty one strains were isolated from 31 children (16 boys,15 girls).The ages ranged from 3 h to 5 months.Among the 31 GBS-positive cultures,erythromycin resistance was found in 25 strains (80.6％),clindamycin resistance was found in 24 strains (77.4％).Three GBS isolates were susceptible to both erythromycin and clindamycin.Two isolates were resistant to erythromycin whilst susceptible to clindamycin.Among the 25 erythromycin-resistant isolates,the constitutive MLSB (cMLSB) was indentified in 23 cases(92.0％).The iMLSB phenotype was not found.Conclusion:Rates of GBS resistance to erythromycin and clindamycin in infants are high.The cMLSB phenotype is common and iMLSB is not found.关键词
婴儿/B族链球菌/克林霉素/耐药Key words
infant/group B streptococcus/clindamycin/resistance分类
医药卫生引用本文复制引用
张交生,王红梅,董意妹,张蕾,张锐沐,邓继岿..深圳市婴儿感染B族链球菌的克林霉素诱导型耐药研究[J].儿科药学杂志,2017,23(5):1-3,3.基金项目
深圳市科技计划项目,编号JCYJ20150403100317058 （）
深圳市卫生计生系统科研项目,编号201402045. （）
