法医学杂志2017，Vol.33Issue(2)：136-140,147,6.DOI:10.3969/j.issn.1004-5619.2017.02.006
IBS评分法鉴定全同胞关系及其临界值查询表的构建
Full Sibling Identification by IBS Scoring Method and Establishment of the Query Table of Its Critical Value
摘要
Abstract
Objective T o establish a query table of IB S critical value and identification pow er for the detection system s w ith different num bers of ST R loci under different false judgm ent standards. Methods Sam ples of 267 pairs of full siblings and 360 pairs of unrelated individuals w ere collected and 19 auto-som al ST R loci w ere genotyped by G oldeneyeTM 20A system . T he full siblings w ere determ ined using IB S scoring m ethod according to the 'R egulation for biological full sibling testing'. T he critical values and identification pow er for the detection system s w ith different num bers of ST R loci under different false judgm ent standards w ere calculated by theoretical m ethods. Results A ccording to the form al IB S scoring criteria, the identification pow er of full siblings and unrelated individuals w as 0.7640 and the rate of false judgm ent w as 0. T he results of theoretical calculation w ere consistent w ith that of sam ple observation. T he query table of IB S critical value for identification of full sibling detection system s w ith different num bers of ST R loci w as successfully established. Conclusion T he IB S scoring m ethod defined by the regulation has high detection efficiency and low false judgm ent rate, w hich provides a relatively conservative result. T he query table of IB S critical value for identification of full sibling detection sys-tem s w ith different num bers of ST R loci provides an im portant reference data for the result judgm ent of full sibling testing and ow ns a considerable practical value.关键词
法医遗传学/同胞关系/短串联重复序列/状态一致性Key words
forensic genetics/sibling relations/short tandem repeat/identity by state (IB S )分类
社会科学引用本文复制引用
李燃,李成涛,赵书民,李海霞,李莉,乌日嘎,张楚楚,孙宏钰..IBS评分法鉴定全同胞关系及其临界值查询表的构建[J].法医学杂志,2017,33(2):136-140,147,6.基金项目
国家自然科学基金面上项目(81273347,81671873) （81273347,81671873）
上海市法医学重点实验室资助项目(17DZ2273200) （17DZ2273200）
上海市司法鉴定专业技术服务平台资助项目(16DZ2290900) （16DZ2290900）
