国际医药卫生导报2017，Vol.23Issue(9)：1293-1297,1300,6.DOI:10.3760/cma.j.issn.1007-1245.2017.09.002
抗骨结核载药缓释支架的研究进展
Advances in research of sustained anti-tuberculosis drug loaded scaffolds
摘要
Abstract
The incidence of bone and joint tuberculosis is the highest in extrapulmonary tuberculosis,accounting for 3％-5％ of all TB cases and 35％-50％ of extrapulmonary tuberculosis.Currently,the clinical treatment is generally excision of the necrotic lesions and then putting anti-tuberculosis drugs to clear the residual tubercle bacillus.However,the drug powders within will soon be washed away by body fluids.Sustained drug loaded scaffolds would on the one hand recover the remaining defect and rebuild the tissues and on the other hand offer sustained local drug release to desired places.Therefore,the efficacy of anti-TB drugs within the organization will be improved greatly and the side effects will be reduced,which is of great clinical value.In this paper,the latest research progress of sustained anti-tuberculosis drug loaded scaffolds is reviewed to provide some ideas for the design of new anti-tuberculosis drug loaded scaffolds.关键词
骨结核/复合物支架/缓释Key words
Bone and joint tuberculosis/Composite scaffolds/Sustained release引用本文复制引用
何青,郭彬彬,尹耀庭,周彦彬..抗骨结核载药缓释支架的研究进展[J].国际医药卫生导报,2017,23(9):1293-1297,1300,6.基金项目
湖南省科委基金项目(2014FJ3037)Project of Science and Technology Committee in Hunan (2014FJ3037) （2014FJ3037）
