摘要
Abstract
Objectives To explore the effects of propofol and etomidate on hemodynamics and adverse reactions in patients undertaking general anesthesia.Methods One-hundred-forty patients scheduled for elective laparoscopic cholecystectomy under general anesthesia from March,2014 to Nov.,2015 were randomly divided into group 1,induced with propofol,and group 2,induced with etomidate.During induction,the blood pressures,heart rates,pain caused by injection,apnea,myoclonus,etc.in both groups were recorded.Results There were statistical differences in heart rate and mean arterial pressure at each time point between these two groups (F=158.341,201.276,P ＜ 0.05).50.00％ patients in group 1 and 96.00％ in group 2 showed no pain caused by injection,with a statistical difference (Z=-2.143,P=0.032).All the patients in group 1 and 62.86％ patients in group 2 showed no myoclonus,with a statistical difference (Z=-2.782,P=-0.028).76.00％ patients in group 1 and 66.00％ in the group 2 showed apnea after anesthesia induction,with a statistical difference (x 2=0.981,P=0.612).Conclusions Comparing with propofol,etomidate is better for its hemodynamic stability and has lower incidence of pain caused by injection.It is a better induction option for patients with hemodynamic fluctuation.关键词
依托咪酯/丙泊酚/麻醉诱导/血液流动学Key words
Etomidate/Propofol/Induction of anesthesia/Hemodynamic stability
