摘要
Abstract
Objective To investigate the clinical effect of glargine and GLP-1 analogue in the treatment of type 2 diabetes mellitus.Methods 118 patients with type 2 diabetes mellitus in our hospital from January 2014 to January 2016 were selected,and randomly divided into control group (59 cases) and study group (59 cases).The patients of two groups were treated with oral metformin.On the basis,the patients in control group were treated with glargine,while the patients in study group were treated with GLP-1 analogue (Liraglutide).The control effect of blood glucose,BMI,HOMA-IR,adverse reactions,and cost-effectiveness were compared between the two groups.Results In the study group,the BMI after treatment was (27.0±1.3)kg/m2,the HOMA-IR was (1.6±0.9),the cost-effectiveness of clinical medication was (5 161.5±14.6),significantly better than those in the control group,with statistically significant differences (P＜0.05).But there was no statistically significant difference in the incidence of adverse reactions between the two groups (5.2％ vs.6.8％,P＞0.05).Conclusion Clinical efficacy of GLP-1 analogue in patients with type 2 diabetes mellitus is significantly better than that of glargine,with good application value.关键词
2型糖尿病/甘精胰岛素/胰升血糖素样肽-1Key words
Type 2 diabetes mellitus/Glargine/GLP-1 analogue
