中医药导报2017，Vol.23Issue(8)：17-20,24,5.
针刀干预对肌筋膜疼痛触发点模型鼠股内侧肌腺苷酸、乳酸含量的影响
Effect of Acupotomy Treatment on the Medial Vastus Muscular Adenine Nucleotide and Lactic Acid of the Trigger Point Model Rats with Myofascial Pain Syndrome
摘要
Abstract
Objective:To observe the medial vastus muscular trigger points'energy metabolism (adenine nucleotide,lactic acid) of the trigger points of rats with the myofascial pain syndrome and the changes of acupotomy intervention,and to explore the biological mechanism of treating the myofascial pain syndrome by acupotomy.Methods:The trigger point model rats were established by the method of crush plus eccentric exercise.The pathological variation of trigger points of rats was observed by electrophysiology.We observed the expression of adenine nucleotide and lactic acid on trigger points through high performance liquid chromatography (HPLC) and the colorimetric method.Then we analyzed statistically the difference among groups.Results:At the end of 8th week of modeling,in the model group,the levels of adenine nucleotide declined significantly (P＜0.05),and the levels of lactic acid increased significantly (P＜0.05).After three times of acupotomy treatment,the levels of adenine nucleotide in the acupotomy therapy group significantly increased,and the levels of lactic acid in the acupotomy therapy group significantly declined,compared with those in the model group (P＜0.01).There were also the significant differences of adenine nucleotide and lactic acid between the acupotomy therapy group and the normal group after three times of acupotomy treatment (P＜0.05).Conclusion:Through releasing and activating the trigger points,acupotomy could promote the release of adenine nucleotide and inhibit the secretion of lactic acid in the local site,improving the continued contracting condition of muscles and reducing the accumulation of metabolism products.In this way,acupotomy could break the vicious circle and finally cure the myofascial pain syndrome.关键词
针刀/触发点/腺苷酸/乳酸/大鼠Key words
acupotomy/trigger points/adenine nucleotide/lactic acid/rat分类
医药卫生引用本文复制引用
杜宁宇,郭长青,张义,芦娟,赵瑞利,徐菁,张伟,梁靖容..针刀干预对肌筋膜疼痛触发点模型鼠股内侧肌腺苷酸、乳酸含量的影响[J].中医药导报,2017,23(8):17-20,24,5.基金项目
国家自然科学基金青年基金项目(81503653),项目名称:针刀疗法对肌肉触发点能量危机状态的影响研究 （81503653）
