解放军医学杂志2017，Vol.42Issue(4)：271-278,8.DOI:10.11855/j.issn.0577-7402.2017.04.01
内皮细胞热损伤机制及其对重要脏器功能的影响
The mechanism of heat-induced damage of endothelial cells and its effect on vital organs
摘要
Abstract
As an important organ of the human body,vascular endothelial cells (VECs) play a vital role in heat stressinduced tissue damage.Its integrity not only serves as a barrier for maintaining vascular permeability but also has major impact on cellular structure and function during acute phase response to heat stress.In heat stroke,a series of acute and complicated pathophysiological changes,including microcirculation change,damage VECs and thereby induce or aggravate multiple organ dysfunction syndrome (MODS).Meanwhile,studies have shown that,during heat stroke,VECs are the major responding cells and one of the most common cells that experience morphological and functional changes.Therefore,VECs damage might be an important mechanism involved in heat stroke.This article reviews the mechanism of heat-induced damage of VECs and its effect on vital organs.关键词
中暑/内皮细胞/微循环/多器官功能衰竭Key words
heat stroke/endothelial cells/microcirculation/multiple organ failure分类
医药卫生引用本文复制引用
苏磊,古正涛..内皮细胞热损伤机制及其对重要脏器功能的影响[J].解放军医学杂志,2017,42(4):271-278,8.基金项目
国家自然科学基金(81671896,81471839) （81671896,81471839）
广东省自然科学基金(S2013030013217)This work was supported by the National Natural Science Foundation of China (81671896,81471839),and the Natural Science Foundation of Guangdong Province (S2013030013217) （S2013030013217）
