实用临床医药杂志2017，Vol.21Issue(7)：35-38,4.DOI:10.7619/jcmp.201707010
不同联合介入方式治疗恶性中心气道重度狭窄患者的疗效观察
Clinical efficacy of different combined interventions in treatment of patients with malignant severe central airway stenosis
摘要
Abstract
Objective To evaluate the value of bronchoscope-guaided different combined interventions in the treatment of patients with malignant severe central airway stenosis.Methods A total of 48 patients with malignant severe central airway stenosis were selected and divided into group A treated with combined interventions including high-frequency electrotome + argon plasma coagulation (APC) + freezing (n =31),while another 17 with combined interventions including high-frequency electrotome + APC + freezing + tracheal stent implantation were designed as group B.The response rate (RR) after initial interventional treatment and the middle-and short-term clinical efficacy after 6-month follow up were observed,and corresponding complications and adverse events were recorded.Results The RR of all patients was 100％,in which group B was significantly better in the increase of airway diameter and increase rate of cross sectional area (CSA) (P ＜ 0.05),but was significantly lower in polypnea index than group A (P ＜ 0.05),but there was no significant difference between two groups in forced expiratory volume in one second (FEV1) in the expected value (FEV1％)(P ＞0.05).During 6-month follow-up,there were significant differences in the average monthly interventional therapeutic frequency and average remission period between two groups (P ＜0.05).No patients had complications immediately after interventional process.During the 6-month follow-up,4 8 patients had different-degree chest pain,hemoptysis and retention of secretes.Conclusion Bronchoscope-guided different combined interventions have excellent efficacy in the treatment of patients with malignant severe central airway stenosis.关键词
恶性中心气道狭窄/高频电刀/氩等离子体凝固/冷冻/支架置入Key words
malignant central airway stenosis/high-frequency electrotome/argon plasma coagulation/freezing/stent implantation分类
医药卫生引用本文复制引用
闫芳,杨增荣,夏宇,焦克岗..不同联合介入方式治疗恶性中心气道重度狭窄患者的疗效观察[J].实用临床医药杂志,2017,21(7):35-38,4.基金项目
新疆维吾尔自治区自然科学基金(2015211C049) （2015211C049）
