林产化学与工业2017，Vol.37Issue(2)：121-128,8.DOI:10.3969/j.issn.0253-2417-2017-02-016
小远志中口山酮类化学成分及生物活性研究
Chemical Constituents and Bioactivities of Xanthones from Polygala sibirica L.var.megalopha Fr.
摘要
Abstract
Eighteen compounds were isolated by ethanol extraction, silica gel column chromatography, Sephadex LH-20 column chromatography, MCI-gel column chromatography and semi-preparative HPLC from the dried roots of Polygala sibirica L.var.megalopha Fr.Their structures were identified as 1,7-dihydroxy xanthone (1), 3,6-dihydroxy-1,2,7,8-tetramethoxy xanthone (2), 1,7-dihydroxy-5,6-dimethoxy xanthone (3), 1,5-dihydroxy-6,7-dimethoxy xanthone (3), 1,5-dihydroxy-6,7-dimethoxy xanthone (4), 6-hydroxy-l,7-dimethoxy xanthone (5), 7-hydroxy-1-methoxy xanthone (6), 3,8-dihydroxy- 1,2,4-trimethoxy xanthone (7), 6,8-dihydroxy-1,2,3-trimethoxy xanthone (8), 1,3,6-trihydroxy-2,7,8-trimethoxy- xanthone (9), 3-hydroxy-1,2,8-trimethoxy xanthone (10), 1,3,7-trihydroxy xanthone (11), 1,6-dihydroxy-2,3-methylene-dioxy-7,8-dimethoxy xanthone (12),1,7-dihydroxy-2,3-dimethoxy xanthone (13), 1,6-dihydroxy-5,7-dimethoxy xanthone (14), 3,7-dihydroxy-1,2-dimethoxy xanthone (15), 3,7- dihydroxy-1,2,8-trimethoxy xanthone (16), 1,2,3,7-tetramethoxy xanthone (17), 1,6-dihydroxy-3,5,7,8-tetramethoxy xanthone (18)by ESI-MS, 1 H NMR, 13 C NMR. All compounds except 13 were isolated from this plant for the first time. The antioxidant and antimicrobial activities of compound 1 - 7 were studied. And the results showed that the compound 4 (IC50 = 12 mg/ L) and compound 1 (IC50 = 13 mg/ L) showed good ABTS scavenging activity and compound 3 (MIC = 217 μmol/ L) had certain inhibitory activity against Staphylococcus aureus.关键词
小远志/口山酮类化学成分/抗氧化/抗菌Key words
Polygala.sibirica L.var.megalopha Fr./xathones/antioxidant/antimicrobial分类
化学化工引用本文复制引用
周凌云,余小红,耿圆圆,华燕..小远志中口山酮类化学成分及生物活性研究[J].林产化学与工业,2017,37(2):121-128,8.基金项目
国家自然科学基金资助项目(31260083) （31260083）
皖南医学院校重点科研项目培育基金(WK2016Z06) （WK2016Z06）
