摘要
Abstract
Objective To explore the relationship between helicobacter pylori (Hp) infection and carotid atherosclerosis and peripheral arterial disease (PAD) in the elderly patients with type 2 diabetes.Methods 413 elderly patients with type 2 diabetes were selected and divided,according to Hp infection,into 2 groups:positive Hp group and negative Hp group;a comparative study was made to blood pressure,blood glucose,lipid profiles,high-sensitivity CRP (hs-CRP),urine albumin,carotid intima-media thickness (IMT) and the occurrence of PAD between the patients in the 2 groups and binary logistic analysis was performed.Results The comparison of diabetes duration,blood pressure,blood glucose,lipid profiles and smoking rate between the 2 groups was of no statistical difference (P＞0.05);hs-CRP and urine albumin to creatinine raio of the patients in positive Hp group were higher than those of the patients in negative Hp group with statistical difference (P ＜ 0.05);the common carotid artery IMT and internal carotid artery IMT of the patients in positive Hp group:(0.99 ± 0.38) mm and (0.80±0.29) rm,were both higher than those of the patients in negativeHp group:(0.88±0.29) mm and (0.74±0.22) mm,(P＜0.01,P＜0.05);the ratio of PAD occurrence in positive Hp group was 48.89％ (88/180),higher than that in negative Hp group (32.19％,75/233) (P＜0.01);binary logistic analysis indicated that Hp infection was the independent risk factor of increased common carotid artery IMT (OR=2.33,P＜0.001) and of PAD (OR=2.72,P＜ 0.001).Conclusions Hp infection is in certain correlation to carotid atherosclerosis and PAD in the elderly patients with type 2 diabetes.关键词
2型糖尿病,老年/幽门螺旋杆菌/颈动脉内中膜厚度/外周动脉疾病Key words
type 2 diabetes, elderly/helicobacter pylori (Hp)/carotid intima-media thickness (IMT)/peripheral arterial disease (PAD)
