老年医学与保健2017，Vol.23Issue(2)：105-108,4.
阿卡波糖控制不佳的老年2型糖尿病患者联合甘精胰岛素或中效胰岛素对血糖的影响
The Influence to the Blood Glucose of Insulin Glargine and Isophane Protamine Insulin in acarbose-poorly-controlled elderly patients with type 2 diabetes mellitus
王曹锋 1蔡文玮 1陈谊 1陈朝婷 1盛净1
作者信息
- 1. 上海交通大学医学院附属第九人民医院老年病科,上海200011
- 折叠
摘要
Abstract
Objective To observe the effect of insulin glargine and isophane protamine insulin application on blood glucose in elderly patients with type 2 diabetes mellitus.Method 90 poorly controlled type 2 diabetes mellitus patients were selected during November 2014 to October 2015 of acarbose monotherapy in our hospital geriatrics clinic.The 90 patients were randomly divided into IPI group and GI group which were treated by recombinant intermediate-acting human insulin (isophane protamine insulin,IPI) or long-acting insulin analogues (glargine insulin,GI) respectively on the basis of treatment with Acarbose.The blood glucose fluctuation and the occurrence of hypoglycemia were compared before and after 8 weeks' treatment.Results The FPG,2 hPG,HbA1c after 8 weeks treatment in two groups were significantly lower than that before treatment,but the basal insulin dose of GI group was significantly less than that of IPI group [(0.14±0.08) IU/kg·d vs (0.26 ±0.11) IU/kg· d,P ＜ 0.01].The blood glucose fluctuation coefficient V of GI group was significantly lower than that of IPI group [(0.96±0.36) vs (2.36±0.27),P＜0.01].The 24 hMBG of GI group was lower than that of IPI group [(6.82 ± 1.35) vs (8.88 ±2.01),P＜ 0.05].High blood glucose (＞ 7.8mmol/L or ＞ 11.1mmol) time ratio of GI group was lower than that of IPI group.The time ratio of hypoglycemia (≤3.9 mmol/L) of GI group was less than that of NPH group.Compared the data in two groups before insulin therapy,it was found that:The blood glucose fluctuation coefficient V of two groups both decreased.The 24h MBG and the high blood glucose (＞ 7.8 mmol/L or ＞ 11.1 mmol) time ratio of two groups also significantly decreased.The hypoglycemia (≤ 3.9 mmol/L) time ratio of GI groups had no significant difference after treatment while in IPI group it was significantly more than that before treatment [(0.40 ±0.13) vs (0.16 ±0.1),P ＜ 0.05].Conclusion Compared with IPI and glucosidase inhibitor (acarbose) combination therapy,insulin glargine (Lantus) and glucosidase inhibitor (acarbose) combination therapy could improve the blood glucose fluctuation,decrease fasting and postprandial blood glucose.关键词
老年人/2型糖尿病/甘精胰岛素/低血糖症Key words
elderly/type 2 diabetes mellitus/glargine insulin/hypoglycemia引用本文复制引用
王曹锋,蔡文玮,陈谊,陈朝婷,盛净..阿卡波糖控制不佳的老年2型糖尿病患者联合甘精胰岛素或中效胰岛素对血糖的影响[J].老年医学与保健,2017,23(2):105-108,4.
