中南医学科学杂志2017，Vol.45Issue(3)：251-254,279,5.DOI:10.15972/j.cnki.43-1509/r.2017.03.009
游泳训练对新生大鼠学习记忆和海马神经发生的影响
Effects of swimming training on the learning and memory andhippocampus neurogenesis in newborn rats
刘鹏英 1张春花 1陈歆 2贺军民1
作者信息
- 1. 湖南省娄底市娄星区人民医院,湖南 娄底 417000
- 2. 湖南省中医药高等专科学校,湖南 株洲 412000
- 折叠
摘要
Abstract
Objective To observe effect of swimming training on learning and memory and hippocampus neurogenesis in neonatal rats.Methods 7-days-old newborn Sprague-Dawley rats were randomly divided into control and swimming training group.From eleventh days after birth,the rats in swimming group were carried on 3-weeks swimming training with no load once a day,60 min every time.Learning and memory was evaluated by Morris water maze.The number of BrdU+/NeuN+ was counted by immunofluorescence double labeling staining.The expression of brain derived neurotrophic factor (BDNF) was tested by Western blot.Results The latency for finding the hidden platform in control and swimming training group was obviously decreased with the training days increasing (all P<0.05).On the second,third and forth day,the latency for finding the hidden platform in swimming training group was significantly decreased compared with control (all P<0.05).Number across platform and the time across platform was significantly increased in swimming training group compared with control (all P<0.05).Number of NeuN+/BrdU+ cells was significantly increased and expression of BDNF was significantly increased in swimming training group compared with control (all P<0.05).Conclusion Swimming training increases capacity of learning and memory in neonatal rats,which mechanism may be related with up-regulation of BDNF expression and increase of neurogenesis in hippocampus of rats.关键词
新生大鼠/游泳训练/学习记忆/海马/神经发生/脑源性神经营养因子Key words
newborn rats/swimming training/hippocampus/neurogenesis/brain derived neurotrophic factor分类
医药卫生引用本文复制引用
刘鹏英,张春花,陈歆,贺军民..游泳训练对新生大鼠学习记忆和海马神经发生的影响[J].中南医学科学杂志,2017,45(3):251-254,279,5.
