中南医学科学杂志2017，Vol.45Issue(3)：266-270,5.DOI:10.15972/j.cnki.43-1509/r.2017.03.013
结肠癌中DLC-1与Moesin的表达及临床病理学意义
The expression and clinical pathological significances ofDLC-1 and Moesin in human colon cancer tissues
摘要
Abstract
Objective To explore the correlation and clinical pathological significances of DLC-1and Moesin in colon cancer tissues.Methods 72 cases of human colon carcinoma tissues with different clinical stage and differentiation degree and matching colon mucosa tissues in paratumor were collected,in which the expression of DLC-1and Moesin were detected by Western blotting and immunohistochemistry,respectively.Results Compared with colon mucosa tissues in paratumor,the expression and positive rates of DLC-1 protein in carcinoma tissues decreased,but Moesin increased significantly.DLC-1 expression was found to inversely correlate with Moesin in colon carcinoma tissues.The positive rate of DLC-1 in poorly-differentiated colon carcinoma tissues was lower than that in well or moderately-differentiated colon cancer tissues.In colon carcinoma tissues at Ⅲ or Ⅳof TNM stage,with lymphatic metastasis and with recurrence or death in less than 5 years,the positive rate of DLC-1 was lower than that at Ⅰ or Ⅱ stage,without lymphatic metastasis and with relapse-free in five years,respectively.The positive rates of Moesin was inverse to DLC-1 in colon carcinoma tissues with different differentiation degree,TNM stage,lymph node metastasis and prognosis.Conclusion The expression of DLC-1 protein decreased and was inversely correlated with Moesin which was increased significantly in colon carcinoma tissues,and Moesin and DLC-1 were highly correlated with tumor differentiation,TNM stage,lymph node metastasis and prognosis of colon cancer.关键词
结肠癌/Moesin/DLC-1/分化/TNM分期/转移Key words
colon cancer/Moesin/DLC-1/differentiation/TNM stage/metastasis分类
医药卫生引用本文复制引用
全胜,陈雄新,华中昌,贺修胜..结肠癌中DLC-1与Moesin的表达及临床病理学意义[J].中南医学科学杂志,2017,45(3):266-270,5.基金项目
2014年湖南省教育厅科研项目(编号:14C0387). （编号:14C0387）
