陕西医学杂志2017，Vol.46Issue(5)：602-604,3.DOI:10.3969/j.issn.1000-7377.2017.05.025
米力农对老年心力衰竭心功能及血清hs-CRP、TNF-α、IL-6水平的影响
Effect of milrinone on cardiac function in elderly patients with heart failure and its impact on serum hs-CRP, TNF-α and IL-6
摘要
Abstract
Objective:To investigate the effect of milrinone on cardiac function in elderly patients with heart failure and its impact on serum hs-CRP, TNF-α and IL-6.Methods:72 cases of elderly patients with chronic heart failure were randomly divided into observation group (n=36) and control group (n=36), the control group received routine anti heart failure treatment, observation of combined application of milrinone in the treatment group, compared two groups of patients with clinical curative effect, cardiac function index before and after treatment between the two groups (echocardiography, serum NT-pro BNP) index, serum NT-pro changes and serum hs-CRP, TNF-alpha, IL-6 level.Results:after treatment, the total efficiency of treatment in the observation group was 91.67%, compared with the control group (75%) was significantly increased, there was significant difference (P<0.05);compared with before treatment, LVEF in the two groups of patients were significantly increased LVEDd and serum NT-pro BNP levels were significantly decreased, the observation group of patients with these indexes better than the control group (P<0.05);after treatment, serum hs-CRP, TNF-alpha and IL-6 levels in the two groups of patients were significantly decreased, and the observation group were lower than the control group, there were significant differences (P<0.05).Conclusion:For the short-term use of milrinone in the treatment of elderly patients with chronic heart failure can significantly improve cardiac function and inhibit inflammatory reaction and improve the clinical efficacy.关键词
心力衰竭,充血性/药物疗法/米力农/治疗应用/肿瘤坏死因子/代谢/白细胞介素6/代谢/老年人Key words
Heart failure,congestive/drug therapy/Milrinone/therapeutic use/Tumor necrosis factor/metabolism/Interleukin-6/metabolism/Aged分类
医药卫生引用本文复制引用
王庆旭,胡晓燕,周致远,李德才,唐焕君,张大勇,胡波,陈涛,杨艳,邸云峰..米力农对老年心力衰竭心功能及血清hs-CRP、TNF-α、IL-6水平的影响[J].陕西医学杂志,2017,46(5):602-604,3.基金项目
四川省绵阳市卫生局科研课题 (201422) （201422）
