物理化学学报2017，Vol.33Issue(5)：903-917,15.DOI:10.3866/PKU.WHXB201702091
可释放一氧化氮纳米材料的研究进展
Recent Research Advancements in NO-Releasing Nanomaterials
摘要
Abstract
Nitric oxide (NO)-an endogenous diatomic molecule-plays key roles in various physiological and pathological processes,including smooth muscle relaxation in blood vessels,immune response,neurotransmission,respiration,and cell apoptosis.The biological functions of this molecule greatly depend on the location,timing,and dosage at which it is released.It is important to develop NO-delivery platforms capable of holding NO stably during storage and subsequently release optimal amounts of NO spatiotemporally at the desired location and time.In this review,recent advancements in the preparation of new exogenous NO donors including diazeniumdiolates,S-nitrosothiols,nitrobenzene,and metal-nitrosyl complexes are discussed.The integration of these NO donors with various nanoplatforms for controlled NO delivery and their potential applications in the biomedical field are highlighted.关键词
控制释放/纳米医学/一氧化氮/NO运输平台/NO供体Key words
Controlled release/Nanomedicine/Nitric oxide/Nitric oxide delivery nanoplatform/Nitric oxide donor分类
化学化工引用本文复制引用
向慧静,刘劲刚,赵彦利..可释放一氧化氮纳米材料的研究进展[J].物理化学学报,2017,33(5):903-917,15.基金项目
The project was supported by the Singapore Academic Research Fund (RG112/15),NTU-Northwestern Institute for Nanomedicine,and National Natural Science Foundation of China (21571062).新加坡学术研究基金(RG112/15),南洋理工大学-西北大学纳米医学联合研究所及中国国家自然科学基金(21571062)资助项目 （RG112/15）
