西南国防医药2017，Vol.27Issue(5)：433-436,4.DOI:10.3969/j.issn.1004-0188.2017.05.001
生脉散配方颗粒的成型工艺研究
Study on molding process of Shengmaisan Formula Granule
摘要
Abstract
Objective To select the optimum molding process of Shengmaisan Formula Granule.Methods The optimum volatile oil inclusion process was selected by orthogonal test,with volatile oil inclusion rate and inclusion yield as the indexes,and the type and amount of excipients for molding formula granule by dry granulation and comprehensive score,with granule forming rate,dissolution rate and moisture absorption as indexes;the critical relative moisture of formula granule was investigated to determine the environmental humidity requirements for granulation and packaging.Results The optimum volatile oil inclusion process was β-cyclodextrin ∶ volatile oil =6(g)∶ 1 (ml);inclusion temperature:30 ℃;ultrasonic inclusion:45 min;thus volatile oil inclusion complex was obtained.In the environment with relative humidity lower than 62％,Shengmaisan Formula Granule was obtained by mixing the granule,which was prepared by dry extract ∶ dextrin =5∶1,adding dextrin and by dry granulation (principal pressure 4.5-5.0 MPa and lateral pressure 0.25-0.30 MPa),with the volatile oil inclusion complex.Conclusion The molding process is reasonable,stable and feasible,and can provide scientific basis for mass production.关键词
生脉散/配方/颗粒/成型/工艺Key words
Shengmaisan Formula Granule/molding process分类
医药卫生引用本文复制引用
张加雄,唐伟革,李立新,何宇新,吴萍..生脉散配方颗粒的成型工艺研究[J].西南国防医药,2017,27(5):433-436,4.基金项目
成都军区医学科学技术研究“十二五”项目计划(C12020) （C12020）
