西南国防医药2017，Vol.27Issue(5)：448-450,3.DOI:10.3969/j.issn.1004-0188.2017.05.006
胰岛素泵持续皮下注射治疗DKA对氧化应激的影响
Effects of continuous subcutaneous injection with insulin pump on oxidative stress in treatment of DKA
耿振儒 1王俊红 2薛阳利 2任丽娜1
作者信息
- 1. 710048西安,陕西省新安中心医院急诊科
- 2. 西安交通大学第二附属医院内分泌科
- 折叠
摘要
Abstract
Objective To compare the effects of continuous subcutaneous injection with insulin pump and multiple subcutaneous insulin injections on oxidative stress in the treatment of diabetic ketoacidosis (DKA).Methods A total of 75 patients with DKA admitted to our hospital were selected and divided into an observation group (odd ones) (n=38) and a control group (even ones) (n=37) according to the odd and even serial number of admission.The two groups received routine basic treatment.On this basis,the observation group was further treated with continuous subcutaneous injection with insulin pump and the control group with multiple subcutaneous insulin injections every day.The clinical indicators,glucose levels,oxidative stress levels and safety between the two groups were compared.Results The time for glucose to reach standard level,the time for blood ketone body to turn negative and blood pH recovery time in the observation group were significantly shorter than those in the control group,and the insulin dosage was also less (P ＜ 0.05).After the treatment,the FPG,2h PG,HblAc,SOD,MDA and GSH-Px in the two groups were greatly improved,but the improvement in the observation group was more significant (P ＜ 0.05).The incidence of hypoglycemia in the observation group was significantly lower than that in the control group (0 vs 13.51％,P ＜ 0.05).Conclusion Continuous subcutaneous injection with insulin pump has better effects and safety on the treatment of DKA and can better improve oxidative stress than and multiple subcutaneous insulin injections,and it is worthy of clinical popularization.关键词
糖尿病/酮症酸中毒/胰岛素泵/持续/皮下注射/疗效/氧化应激Key words
DKA/insulin pump/continuous subcutaneous injection/effect/oxidative stress分类
医药卫生引用本文复制引用
耿振儒,王俊红,薛阳利,任丽娜..胰岛素泵持续皮下注射治疗DKA对氧化应激的影响[J].西南国防医药,2017,27(5):448-450,3.
