新医学2017，Vol.48Issue(5)：338-341,4.DOI:10.3969/j.issn.0253-9802.2017.05.011
神经钙黏素、可溶性细胞间黏附分子-1与血管内皮生长因子在多发性骨髓瘤患者中的表达及临床意义
Expression levels and clinical significance of N-cadherin, soluble intercellular adhesion molecule-1 and vascular endothelial growth factor in patients with multiple myeloma
摘要
Abstract
Objective To investigate the expression levels and clinical significance of N-Cadherin, soluble intercellular adhesion molecule-1(sICAM-1)and vascular endothelial growth factor (VEGF) in patients with multiple myeloma. Methods Seventy multiple myeloma patients were assigned into the observation group and 70 healthy subjects were allocated into the control group. The percentage of serum N-Cadherin-positive cells among CD138+ /CD38+ cells was measured by flow cytometry to represent the expression level of N-Cadherin. The expression levels of serum sICAM-1 and VEGF in all subjects were quantitatively measured by ELISA. The expression of N-Cadherin, sICAM-1 and VEGF was statistically compared among patients of different clinical staging. Results In the observation group, the expression levels of serum N-Cadherin, sICAM-1 and VEGF were significantly up-regulated compared with those in the control group (all P<0.05). No statistical significance was identified in the expression of serum N-Cadherin among patients of different clinical staging (P>0.05). The expression levels of sICAM-1 and VEGF significantly differed among patients of different clinical staging (all P<0.05). Conclusions N-Cadherin is highly expressed in patients diagnosed with multiple myeloma, which is not correlated with the disease staging. However, detection of sICAM-1 and VEGF is of potential significance for estimating the incidence and progression of multiple myeloma.关键词
神经钙黏素/可溶性细胞间黏附分子-1/血管内皮生长因子/多发性骨髓瘤/临床意义Key words
N-Cadherin/Soluble intercellular adhesion molecule-1/Vascular endothelial growth factor/Multiple myeloma/Clinical significance引用本文复制引用
李丹,何伟锋,岳文婧..神经钙黏素、可溶性细胞间黏附分子-1与血管内皮生长因子在多发性骨髓瘤患者中的表达及临床意义[J].新医学,2017,48(5):338-341,4.基金项目
惠州市科技计划项目(2015Y048) （2015Y048）
