中国肺癌杂志2017，Vol.20Issue(5)：326-333,8.DOI:10.3779/j.issn.1009-3419.2017.05.05
肺癌合并眼部转移:单中心回顾性研究并文献综述
Ocular Metastasis in Lung Cancer: a Retrospective Analysis in a Single Chinese Hospital and Literature Review
徐燕 1孙伊多 2赵静 1陈闽江 1蒋德利娜 1李龙芸 1钟巍 1王孟昭1
作者信息
- 1. 100730 北京,中国医学科学院,北京协和医学院,北京协和医院呼吸内科
- 2. 100730 北京,中国医学科学院,北京协和医学院,北京协和医院风湿免疫科
- 折叠
摘要
Abstract
Background and objective Eye is a rare site of lung cancer metastasis, and ocular metastasis is one of the largest challenges to cancer patients' quality of life (QOL). Here we present our experience on ocular metastasis of lung cancer and review relevant literature in an attempt to investigate the clinical features, treatment, and prognosis of these tumors. Methods The records of 9 patients with ocular metastasis of lung cancer treated at our hospital were analyzed. A literature re-view identified 42 cases reported in the last 10 years and their medical records were retrospectively estimated. Results The me-dian age of our patients was 51 years (range 41-61). Diagnosis of lung cancer included non-small cell lung carcinoma (NSCLC) in 7 patients, in which adenocarcinoma (ADC) were recorded in 6 patients, small cell lung carcinoma (SCLC) in 1 patient, and unknown in 1 patient. The site of ocular metastasis included choroid (n=8) and iris (n=1). In the literature review, SCLC con-stituted 21.4% (n=9) and ADC constituted 47.6% (n=20). Choroid presented to be the most common site for eye metastasis (66.7%, n=28). As for disease control rate, systemic chemotherapy for lung cancer patients with ocular metastasis presented to be only 28%. Meanwhile, combination of systemic treatment with ocular treatment could improve patients' eye symptoms effectively. Conclusion The most common lung cancer that metastasizes to the eye is ADC. The choroid is the most common site for ocular metastasis. Ocular treatment can improve patients' eye symptoms, while the effect of systemic chemotherapy treatment is limited.关键词
肺肿瘤/眼部肿瘤/肿瘤转移Key words
Lung neoplasm/Eye neoplasms/Neoplasm metastasis引用本文复制引用
徐燕,孙伊多,赵静,陈闽江,蒋德利娜,李龙芸,钟巍,王孟昭..肺癌合并眼部转移:单中心回顾性研究并文献综述[J].中国肺癌杂志,2017,20(5):326-333,8.
