中国康复理论与实践2017，Vol.23Issue(5)：575-579,5.DOI:10.3969/j.issn.1006-9771.2017.05.018
海马亚区磁共振成像T2信号评估遗忘型轻度认知障碍的可行性
Application of Hippocampal Subfield Magnetic Resonance Imaging T2 Signal Intensity for Amnestic Mild Cogni-tive Impairment
摘要
Abstract
Objective To apply the MRI T2 signal intensity of hippocampal subfield in patients with amnestic mild cognitive impairment (aMCI) as early imageology. Methods From October, 2014 to August, 2015, 20 aMCI patients accepted cognitive training (training group), 20 aMCI patients accepted speech communication (speech group), and 20 age-and gender-matched healthy old people (control group) were scanned with MRI using FSE-T2 sequence. The margin of hippocampal subfields were outlined manually for each side to measure the T2 sig-nal intensity. The correlation between hippocampal T2 signal intensity and the scores of Mini-Mental State Examinatlon (MMSE) was ana-lyzed in the training group. Results Before treatment, T2 signal intensity in the bilateral hippocampal head was significantly high in the aM-CI patients compared with that in the control group (P<0.05). After treatment, T2 signal intensity in left hippocampal head decreased in the training group compared with that in the speech group (P<0.05), similar to the control group (P>0.05). There was negative correlation be-tween left hippocampal head's T2 signal intensity and the scores of MMSE in the training group before and after treatment (r=-0.61, r=-0.54, P<0.05). Conclusion The T2 signal intensity in left hippocampal head may respond to the cognitive function in patients with aMCI in the early stage, that could be used for diagnosis and evaluation in clinic.关键词
轻度认知障碍/海马/磁共振成像/T2加权信号/评定/诊断Key words
mild cognitive impairment/hippocampus/magnetic resonance imaging/T2-weighted signal/evaluation/diagnosis分类
医药卫生引用本文复制引用
张小洁,曹志宏,罗一烽,刘瑜,吴立伟,单海荣,刘怡文,李月峰,王冬青..海马亚区磁共振成像T2信号评估遗忘型轻度认知障碍的可行性[J].中国康复理论与实践,2017,23(5):575-579,5.基金项目
1.江苏省卫计委面上项目(No.H201656) （No.H201656）
2.无锡市科技计划项目(No.CSZ0N1632 （）
No.CSEW1N1111) （）
3.无锡市卫生计生科技成果和适宜技术推广项目(No.T201601) （No.T201601）
4.无锡市卫计委科研项目(No.Z201610 （）
No.ML201320). （）
