摘要
Abstract
AIM:To systematically review the efficacy of Zhenyuan capsule combined with western medicine for chronic heart failure.METHODS:Databases including PubMed,The Cochrane Library,EMbase,CBM,CNKI,VIP,Wanfang were searched to collect randomized controlled trials about Zhenyuan capsule in treating chronic heart failure.Valid data were selected for a Meta-analysis by document screening and quality evaluation.RESULTS:A total 11 RCTs involving 1 006 cases were included.The results of Meta-analysis showed that the combination of Zhenyuan capsule and western medicine were superior in clinical effect [OR =4.35,95％ CI (2.97,6.36),P＜0.000 01],left ventricular ejection fraction [MD =7.89,95％ CI (4.24,11.54),P ＜0.000 1],N-terminal pro brain natriuretic peptide [MD =572.24,95％ CI (427.16,717.32),P ＜0.000 01],cardiac output[MD =0.79,95％ CI (0.61,0.98),P ＜ 0.000 01],compared with the pure western medicine treatment.CONCLUSION:Current results indicated better clinical efficacy of the combination of Zhenyuan capsule and western medicine in the treating chronic heart failure compared with the pure western medicine treatment.Yet,due to the limited results of the included studies,it still needs to be verified by more researches.关键词
振源胶囊/慢性心力衰竭/随机对照试验/Meta分析Key words
Zhenyuan capsule/chronic heart failure/randomized controlled trial/Meta-analysis分类
医药卫生
