中国临床药理学与治疗学2017，Vol.22Issue(3)：305-311,7.
脐带间充质干细胞治疗严重膝骨关节炎的对照研究
Therapeutic effect of human umbilical cord-derived mesenchymal stem cells for severe knee osteoarthritis
摘要
Abstract
AIM:To explore the therapeutic effect of two methods of knee joint cavity injection in treating sodium hyaluronate and human umbilical cord-derived mesenchymal stem cells for severe knee osteoarthritis by evaluating pain degree,clinical effect,radiological change,and safety.METHODS:In this semi-blind parallelling study,44 severe knee osteoarthritis patients were randomly divided into 3 groups.16 patients in group A were injected with sodium hyaluronate 5 times individually.15 patients in group B were injected with human umbilical cord-derived mesenchymal stem cells twice.13 patients in group C were injected with human umbilical cord-derived mesenchymal stem cells 4 times.VAP scores,American Knee Society Knee scores,and Kellgren-Lawrence radiographic evaluation were evaluated.Follow-up were conducted 3,6 and 12 months after treatment for recording clinical examination,evaluating observed indicators and safety assessment.Laboratory tests and X-ray examination of the knee were checked 6 and 12 months after treatment independently.RESULTS:VAP scores:significant difference were found in three groups before and 3,6,12 months after treatment;results showed that there were significant difference in group A 12 months after treatment comparing with group B and group C.AKS scores:significant difference were found in group B and group C before and 3,6,12 months after treatment;AKS Function:significant difference were found in group B and group C before and 3,6,12 months after treatment;Kellgren-Lawrence radiographic evaluation:no significant difference were found during the study.CONCLUSION:Comparing with sodium hyaluronate injection,the therapeutic effect of human umbilical cord-derived mesenchymal stem cells for severe knee osteoarthritis was more effective in relieving pain and improving joint function.Four times injections are better than two times injection.关键词
骨关节炎/脐带间充质干细胞/透明质酸钠Key words
osteoarthritis/human umbilical cord derived mesenchymal stem cells/sodium hyaluronate分类
医药卫生引用本文复制引用
杨孝兵,蒋峰,张帆,施星芬,刘丽敏,徐志国..脐带间充质干细胞治疗严重膝骨关节炎的对照研究[J].中国临床药理学与治疗学,2017,22(3):305-311,7.基金项目
浙江省湖州市生物医药重大专项计划(2011ZD2007) （2011ZD2007）
