中国临床药理学与治疗学2017，Vol.22Issue(3)：342-349,8.
三维细胞模型在抗肿瘤药物早期药代动力学筛选中的应用进展
Application advance on screening of anti-cancer drugs in the early stage of pharmacokinetics based on 3D cell culture model
摘要
Abstract
Despite significant improvements in ways to treat cancer,numerous patients still die from it.One of the important reasons for this problem is that high failure of clinical transformation ratio due largely to poor PK/PD behavior.As time moves on,many new data increasingly reveal that traditional pharmacokinetics study in vivo cannot totally explain the efficacy of drug targeting on the intra-cell.Previously 2D cell culture has been the most popular in vivo models in drug screening and R&D.However,2D cell culture techniques do not faithfully replicate all of the mechanical and biochemical signals present in vivo.It is necessary to improve the early drug developmental stage to evaluate new drugs or drug combinations.3D cell culture systems can reproduce the characteristics of solid tumors in vivo vividly.Growing cells such as 3D models used in cellular pharmacokinetics break a new through on cell based assay and evaluation of anti-cancer drugs.This review aims first to shortly report on 3D culture systems currently and second to introduce the applications and advantages of cellular pharmacokinetics evaluation of anti-cancer drugs based on 3 D cell model.关键词
三维细胞/药代动力学/肿瘤微环境/早期药物筛选Key words
3D cell culture/pharmacokinetics/tumor microenvironment/early drug screening分类
医药卫生引用本文复制引用
鲁萌,周芳,刘嘉莉,贾元威,倪苹,王广基,张经纬..三维细胞模型在抗肿瘤药物早期药代动力学筛选中的应用进展[J].中国临床药理学与治疗学,2017,22(3):342-349,8.基金项目
国家自然科学基金面上项目(81573494) （81573494）
国家自然科学基金青年项目(81503236) （81503236）
江苏省自然科学基金青年项目(BK20160108) （BK20160108）
安徽省科技厅自然科学基金项目(1608085QH212) （1608085QH212）
南京大学中央高校基本科研业务费项目(021414380173) （021414380173）
安徽省高校优秀青年人才支持计划重点项目(gxyqZD2016178) （gxyqZD2016178）
