中国临床药理学与治疗学2017，Vol.22Issue(3)：355-360,6.
植物雷公藤主要抗癌抗炎活性成分研究进展
Progress of the study of anticancer and anti-inflammatory bioactive compounds of Tripterygium wilfordii
摘要
Abstract
Tripterygium wilfordii (TW) is a Chinese medicine herb which has been used widely and successfully for centuries in treating immunological disorders and inflammatory diseases.Up to now more than 46 diterpenoids,20 new triterpenoids,26 alkaloids and other small molecules have been isolated and identified from this plant.The diterpenoid epoxide triptolide,the quinone triterpene celastrol and the triptolide derivative tripchlorolide are amomg the bioactive compounds of TW with potent anti-inflammatory and anticancer effects.This review discusses mechanistic studies into these three bioactive compounds and illustrates their potential clinical use in the treatment of cancer and inflammatory diseases.关键词
雷公藤/雷公藤甲素/雷公藤红素/雷公藤氯内酯醇/抗癌/抗炎Key words
Tripterygium wilfordii/triptolide/celastrol/tripchlorolide/anticancer/anti-inflammation分类
医药卫生引用本文复制引用
刘文成,谭布珍,方玉婷,占欣璐,王玉..植物雷公藤主要抗癌抗炎活性成分研究进展[J].中国临床药理学与治疗学,2017,22(3):355-360,6.基金项目
国家自然科学基金(81260382) （81260382）
江西省自然科学基金(20161BBG70218) （20161BBG70218）
