中国免疫学杂志2017，Vol.33Issue(5)：660-664,5.DOI:10.3969/j.issn.1000-484X.2017.05.005
瘦素受体基因Gln223Arg位点多态性与哮喘和代谢综合征之间关系的研究
Associations of polymorphism of leptin receptor gene Gln223Arg with asthma and metabolic syndrome
高俊杰 1秦苗 2徐瑞金 1张静 1葛云洁1
作者信息
- 1. 青岛市市立医院干部保健科,青岛266071
- 2. 青岛大学附属医院,青岛266002
- 折叠
摘要
Abstract
Objective:To investigate the relationship of polymorphism of leptin receptor gene Gln223Arg with asthma and metabolic syndrome.Methods: Collected 120 asthma patients,92 metabolic syndrome patients,54 asthma combined metabolic syndrome patients and 81 normal controls.According to the severity,the asthma patients were divided into mild-medium group and severe group.The serum leptin level was measured by ELISA,the genotypes of leptin receptor were analyzed by the method of polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP),and statistcs of each subject′s MBI,blood pressure,lung function and fasting blood glucose were collected.Results: ①There were significant differences in genotype and allele frequency in leptin receptor gene Gln223Arg between the metabolic syndrome group,asthma combined metabolic syndrome group and normal control group(P<0.05).②The allele frequency and genotype in leptin receptor gene Gln223Arg were significant different between the severe asthma group and normal control group(P<0.05).③The serum leptin level,BMI and systolic blood pressure of AA+AG genotype group were significiant higher than GG genotype group(P<0.05),while the value of FEV1% and FEV1/FVC of lung function were lower than GG genotype group(P<0.05).Conclusion: Leptin receptor gene Gln223Arg polymorphism is correlated with asthma and metabolic syndrome,and by causing leptin resistance,the A allele might be the genetic factor that contribute to individual susceptibility for asthma and metabolic syndrome.关键词
哮喘/代谢综合征/瘦素/瘦素受体/基因多态性Key words
Asthma/Metabolic syndrome/Leptin/Leptin receptor/Gene polymorphism分类
医药卫生引用本文复制引用
高俊杰,秦苗,徐瑞金,张静,葛云洁..瘦素受体基因Gln223Arg位点多态性与哮喘和代谢综合征之间关系的研究[J].中国免疫学杂志,2017,33(5):660-664,5.
