中国免疫学杂志2017，Vol.33Issue(5)：679-683,5.DOI:10.3969/j.issn.1000-484X.2017.05.009
毒力因子乙酰基转移酶抑制金黄色葡萄球菌感染引起的巨噬细胞死亡
Virulence factor O-acetyltransferase A inhibits Staphylococcus aureus infection-induced macrophage death
冯世源 1刘真真 1胡桂秋 1于水星 1杨勇军 1杜崇涛 1陈巍1
作者信息
摘要
Abstract
Objective:To explore the effect of the virulence factor OatA during Staphylococcus aureus infection.Methods: In vitro,wild type of Staphylococcus aureus USA300,OatA gene deletion strain or OatA gene complemented strain were used to infect mice bone marrow divided macrophages (BMDMs).Subsequently BMDMs were separated and the case of cell death were detected.In vivo,mice pulmonary infection model was constructed with nasal inhalation of Staphylococcus aureus.Alveolar macrophages were isolated and the case of cell death were detected.Results: In contrast to wild type and OatA gene complemented strain,OatA gene deletion strain induced severer macrophage death both in vitro and in vivo.Conclusion: The virulence factor OatA inhibits Staphylococcus aureus infection-induced macrophage death.关键词
金黄色葡萄球菌/OatA/巨噬细胞/细胞死亡Key words
Staphylococcus aureus/OatA/Macrophages/Cell death分类
医药卫生引用本文复制引用
冯世源,刘真真,胡桂秋,于水星,杨勇军,杜崇涛,陈巍..毒力因子乙酰基转移酶抑制金黄色葡萄球菌感染引起的巨噬细胞死亡[J].中国免疫学杂志,2017,33(5):679-683,5.
