中国全科医学2017，Vol.20Issue(14)：1675-1679,5.DOI:10.3969/j.issn.1007-9572.2017.14.005
新疆维吾尔族女性宫颈癌终身一次筛查适宜起始年龄研究
Optimal Starting Age for Xinjiang Uygur Women Undergoing Once-in-a-lifetime HPV DNA Test for Cervical Cancer Screening
摘要
Abstract
Background The incidence and mortality rates of cervical cancer are higher in Xinjiang Uygur women compared with the national average.Furthermore,cervical cancer in Xinjiang Uygur women presents different characteristics with younger onset age compared with it in the Han women.It was found that some of the Uygur women only undergo the human papillomavirus (HPV) DNA test for screening cervical cancer once during the lifetime.Objective To estimate the effects of regimens about once-in-a-lifetime HPV DNA test for cervical cancer screening with different starting ages in Xinjiang Uygur women,so as to predict the optimal age for these women undergoing the screening.Methods We constructed a Markov model with a simulated cohort of 100 000 Xinjiang Uygur women based on the data obtained from field surveys and references between 2013 and 2016,in combination with basic principles to construct the Markov model,cervical cancer natural history and screening regimens.The parameters used in the Markov model were from the previous relative studies,and the cycle was determined as 1 year.By repeated cycle operations,the effects of using four regimens of once-in-a-lifetime HPV DNA test for cervical cancer screening which varied with different screening starting ages (30,35,40 and 45) were predicted and compared.Results The number of cervical cancer cases were 967,1 005,1 027,1 044 and the number of deaths were 9,11,13,10 respectively in the starting age of 30,35,40 and 45 for cervical cancer screening.Compared with the natural population,the incidence and mortality rates of cervical cancer were all lower in women underwent the screening,specifically,the incidence rate of cervical cancer dropped by 70.66%,69.51%,68.84%,68.32%,respectively and the mortality rate of cervical cancer fell 70.00%,63.33%,56.67%,66.67%,respectively,in the females who started to screen cervical cancer at the age of 30,35,40 and 45.Sensitivity analysis found that the optimal starting age for screening the cervical cancer was 30 despite different parameters were taken as the sensitivity of HPV DNA test and coverage rate,and these proved that the model has good stability.Conclusion Thirty is the optimal starting age for cervical cancer screening,which reduce the incidence and mortality rates of cervical cancer effectively.关键词
宫颈肿瘤/筛查/年龄/Markov链/维吾尔族Key words
Uterine cervical neoplasms/Screening/Age/Markov chains/Uygur nationality分类
医药卫生引用本文复制引用
寇飞,闫小龙,韦玉洁,刘明珠,井明霞..新疆维吾尔族女性宫颈癌终身一次筛查适宜起始年龄研究[J].中国全科医学,2017,20(14):1675-1679,5.基金项目
新疆生产建设兵团博士基金专项(2013BB015) （2013BB015）
