中国全科医学2017，Vol.20Issue(14)：1689-1692,4.DOI:10.3969/j.issn.1007-9572.2017.14.008
α-烯醇化酶在恶性胸腔积液诊断中的应用研究
Value of Alpha-enolase in the Diagnosis of Malignant Pleural Effusion
摘要
Abstract
Objective To study the clinical value of alpha-enolase in the diagnosis of malignant pleural effusion.Methods Inpatients with pleural effusions were recruited from the Department of Respiratory Medicine and Department of Thoracic Surgery,First Affiliated Hospital of Kunming Medical University from September 2014 to September 2015.Enzyme-linked immunosorbent assay(ELISA) was used to detect the concentration of alpha-enolase in pleural effusions.Receiver operating characteristic(ROC) curve was adopted to evaluate the value of alpha-enolase in the diagnosis of malignant pleural effusion.Results Of the 150 patients with pleural effusions,there were 50 patients with malignant pleural effusions(29 cases of lung adenocarcinoma,1 case of small cell lung cancer,20 cases of undifferentiated type of lung cancer),50 with exudative pleural effusions due to tuberculosis,and 50 with parapneumonic effusions.The concentrations of alpha-enolase in pleural effusions differed significantly among these 3 kinds of patients(P<0.05),specifically,they were higher in patients with malignant pleural effusions than in those with exudative pleural effusions due to tuberculosis or with parapneumonic effusions(P<0.05),but no significant differences in concentrations of alpha-enolase were found between patients with exudative pleural effusions due to tuberculosis and those with parapneumonic effusions(P>0.05).For diagnosing malignant pleural effusion,the area under the curve(AUC) of ROC of alpha-enolase was 0.866,the optimum cut-off point was 4.22 μg/L based on the maximum value of Youden′s index(0.74),the sensitivity and specificity at the optimum cut-off point was 88%,86%,respectively.Conclusion The concentration of alpha-enolase in malignant pleural effusion is significantly higher than that in exudative pleural effusion due to tuberculosis and in parapneumonia pleural effusion.The high sensitivity and specificity of the alpha-enolase in the diagnosis of malignant pleural effusion indicates that it can act a new tumor marker for malignant pleural effusion.关键词
胸腔积液,恶性/磷酸丙酮酸水合酶/灵敏度/特异度Key words
Pleural effusion,malignant/Phosphopyruvate hydratase/Sensitivity/Specificity分类
医药卫生引用本文复制引用
李汝芳,刘凌,王旭明,武江海,冯家钢,赵芝焕..α-烯醇化酶在恶性胸腔积液诊断中的应用研究[J].中国全科医学,2017,20(14):1689-1692,4.基金项目
云南省卫生科技计划内设机构项目(2014NS165) （2014NS165）
