中国全科医学2017，Vol.20Issue(15)：1813-1818,6.DOI:10.3969/j.issn.1007-9572.2017.15.006
同等肾功能下老年人认知功能障碍与血肌酐水平的关系
Relationship between Cognition Impairment and Serum Creatinine Level of the Elderly at the Same Level of Renal Function
摘要
Abstract
Background The relationship between renal function and cognitive function remains controversial nowadays.There are many factors affecting the cognitive impairment(CI) of the elderly,but the association between serum creatinine(Scr) and CI in the elderly is rarely reported.Objective To investigate the relationship between CI and Scr level of the elderly under the same condition of renal function,and to provide the theoretical basis and clinical basis for the clinical treatment of CI in the elderly.Methods According to the inclusion criteria,1 757 old people from 31 villages of Jiang′an town in Rugao,Jiangsu province were enrolled as research subjects by stratified random sampling method from November 13th,2014 to December 21st,2014.The general information of the subjects was collected and the cognitive function was evaluated by HDS-R.According to HDS-R total score,those >21.5 were assigned into non-cognitive impairment(NCI),≤21.5 were assigned into CI.Laboratory examination results including the level of total cholesterol(TC),triacylglycerol(TG),low density lipoprotein cholesterol(LDL-C),high density lipoprotein cholesterol(HDL-C),and Scr and estimated glomerular filtration rate(eGFR) were recorded.Renal function was classified according to eGFR:grade Ⅰ,normal renal function,eGFR≥90 ml·min-1·(1.73 m2)-1;grade Ⅱ,mild injury of renal function,60 ml·min-1·(1.73 m2)-1≤eGFR<90 ml·min-1·(1.73 m2)-1;grade ≥Ⅲ,moderate-to-severe injury of renal function,eGFR<60 ml·min-1·(1.73 m2)-1.Results Among the 1 757 subjects,there were 820 males and 937 females with an average age of(75.3±3.9);823 with NCI and 934 with CI;renal function classification:275 subjects in grade Ⅰ(154 with NCI and 121 with CI);1 001 in grade Ⅱ(513 with NCI and 488 with CI);481 in grade ≥Ⅲ(156 with NCI and 325 with CI).In renal function group of grade Ⅰ,proportion of males and level of Scr of subjects with NCI were higher than those of subjects with CI,while incidence of stroke and coronary heart disease and level of TG were lower than those of subjects with CI(P<0.05).In renal function group of grade Ⅱ,proportion of males and level of Scr of subjects with NCI were higher than those of subjects with CI,and their age and TG level were lower than those of subjects with CI(P<0.05).In renal function group of grade ≥Ⅲ,proportion of males and level of Scr of subjects with NCI were higher than those of subjects with CI,and their age was lower than that of subjects with CI(P<0.05).In renal function group of grade Ⅰ,the total score of HDS-R was positively correlated with Scr level(r=0.506,P<0.001);in renal function group of grade Ⅱ,the total score of HDS-R was positively correlated with Scr level(r=0.444,P<0.001);in renal function group of grade ≥Ⅲ,the total score of HDS-R was positively correlated with Scr level(r=0.233,P<0.001).Conclusion Under the same condition of renal function,higher level of Scr has a protective effect on CI of the elderly,and works well under good condition of renal function.关键词
认知障碍/血肌酐/老年人/肾功能Key words
Cognition disorders/Serum creatinine/Aged/Renal function分类
医药卫生引用本文复制引用
李淑娟,李言洵,刘倩,蒋晓燕,王笑峰,胡志灏,胡文立..同等肾功能下老年人认知功能障碍与血肌酐水平的关系[J].中国全科医学,2017,20(15):1813-1818,6.基金项目
国家自然科学基金资助项目(81301015,81571372,81670465) （81301015,81571372,81670465）
北京市自然科学基金资助项目(7141001) （7141001）
