中国全科医学2017，Vol.20Issue(15)：1903-1905,1910,4.DOI:10.3969/j.issn.1007-9572.2017.15.023
锥形束CT引导下乳腺癌保乳术后调强放疗摆位误差及配准方式分析
Setup Errors and Registration Algorithm of Intensity Modulated Radiation Therapy after Breast Conserving Surgery of Breast Cancer Based on Cone-beam CT
摘要
Abstract
Objective To investigate the setup errors and registration algorithm under different breast thickness of intensity modulated radiation therapy(IMRT) after breast-conserving surgery of breast cancer based on cone-beam CT(CBCT).Methods Eighty five patients who received IMRT after breast conserving surgery in Department of Radiotherapy of the First Affiliated Hospital of Wenzhou Medical University from March to October 2016 were selected.Based on the onboard CBCT of Elekta Synergy accelerator,setup verification was made before IMRT treatment.Match the CBCT reconstructed image with the scheduled CT image.The setup error in the six-dimensional direction was calculated,and the above error on-line was automatically calibrated.The thickness of the breast of each patient(the largest diameter of the breast tissue,that is,the most salient point of the breast tissue to the nearest margin of the chest wall) was measured,and based on the bone-based registration and grey-based registration,the setup error of horizontal movement in X(left and right),Y(upper and lower),Z(front and rear) axes and the sagittal position(GX),coronal position(GY) and transverse position(GZ) were comparatively analyzed.Results There was significant difference in the setup error between the X axis and the GY of the 85 patients based on the bone-based registration and grey-based registration(P<0.05).In the automatic bone-based registration,there was no significant difference in the setup error among A group(thickness of breast ≤30 mm),B group(30< thickness of breast ≤45 mm) and C group(thickness of breast >45 mm)(P>0.05).In the automatic grey-based registration,there was no significant difference in the setup error of each direction among the three groups(P>0.05).Conclusion There are no significant differences in setup errors under different breast thickness of IMRT after breast-conserving surgery of breast cancer.The grey-based registration is recommended first in the two registration methods.The error calibration before radiotherapy can significantly improve the accuracy of breast cancer treatment,and thus realize the precise radiotherapy.关键词
乳腺肿瘤/放射疗法,调强适形/锥形束CT/配准/摆位误差Key words
Breast neoplasms/Radiotherapy,intensity-modulated/Cone-beam CT/Registration/Setup errors分类
医药卫生引用本文复制引用
吴志勤,余建义,阎华伟,杨桂强,林立,黄包记,王志玮,潘涵慧,金献测..锥形束CT引导下乳腺癌保乳术后调强放疗摆位误差及配准方式分析[J].中国全科医学,2017,20(15):1903-1905,1910,4.基金项目
国家自然科学基金面上项目(11675122) （11675122）
浙江省自然科学基金资助项目(LY16H160046) （LY16H160046）
